重新审视免疫球蛋白分子内信号假说。
Revisiting the Immunoglobulin Intramolecular Signaling Hypothesis.
作者信息
Bowen Anthony, Casadevall Arturo
机构信息
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
出版信息
Trends Immunol. 2016 Nov;37(11):721-723. doi: 10.1016/j.it.2016.08.014. Epub 2016 Sep 14.
Abstract
A generation ago, the immunoglobulin intramolecular signaling, or allosteric, hypothesis was abandoned in favor of the associative hypothesis, which posited that Fc receptor crosslinking produced the increased affinity of antigen-antibody complexes. This essay argues that there is sufficient evidence to resuscitate the allosteric hypothesis, at least for some antibodies.
摘要
一代人以前，免疫球蛋白分子内信号传导或变构假说被摒弃，转而支持结合假说，该假说认为Fc受体交联产生了抗原-抗体复合物亲和力的增加。本文认为，至少对于某些抗体而言，有足够的证据来复兴变构假说。
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