Gardner Murray
School of Medicine, University of California, Davis, CA, USA.
J Med Primatol. 2016 Oct;45(5):212-4. doi: 10.1111/jmp.12234. Epub 2016 Sep 19.
For the past 30 years, Simian AIDS has provided an indispensible animal model for the human disease. This historical perspective highlights the circumstances leading to the creation of this experimental model.
Historical information and stored non-human primate (NHP) specimens, including isolates of Simian immunodeficiency virus (SIV), were analyzed by molecular epidemiologic methods to trace the lineage and transmission of SIV among NHPs at US primate centers.
The rhesus and stump-tailed macaque models of Simian AIDS are the result of the accidental transmission of SIV from healthy sooty mangabey carriers to naïve macaques during the course of human kuru experimental transmission studies at UC Davis during the 1960s.
Simian AIDS, first recognized in the 1980s, is the accidental result of experimental kuru transmission experiments carried out in the 1960s, which led to the discovery of infectious prions but inadvertently transmitted SIV, unknown at that time, from sooty mangabeys to macaques.
在过去30年里，猴艾滋病为人类疾病提供了不可或缺的动物模型。这一历史视角突出了导致该实验模型创建的种种情况。
通过分子流行病学方法分析历史信息和储存的非人灵长类动物（NHP）标本，包括猴免疫缺陷病毒（SIV）分离株，以追踪美国灵长类动物中心的NHP中SIV的谱系和传播情况。
猴艾滋病的恒河猴和短尾猕猴模型是20世纪60年代在加州大学戴维斯分校进行人类库鲁病实验传播研究期间，SIV从健康的乌黑白眉猴携带者意外传播到未感染的猕猴的结果。
20世纪80年代首次确认的猴艾滋病是20世纪60年代进行的库鲁病实验传播实验的意外结果，该实验导致了传染性朊病毒的发现，但无意中将当时未知的SIV从乌黑白眉猴传播给了猕猴。
