Brace R A, Wolf E J
Department of Reproductive Medicine, University of California, San Diego, La Jolla 92093.
Am J Obstet Gynecol. 1989 Aug;161(2):382-8. doi: 10.1016/0002-9378(89)90527-9.
The purpose of this study was to provide a quantitative characterization of the changes in amniotic fluid volume that occur throughout gestation. From 705 published amniotic volumes for normal pregnancies, we found that after log transformation, amniotic fluid volume had a uniform variability over 8 to 43 weeks' gestation. Thus the 95% confidence interval covered the range of 1/2.57 to 2.57 times the mean volume at any given gestational age. Contrary to expected trends, mean amniotic fluid volume did not change significantly between 22 and 39 weeks and averaged 777 ml, with the 95% confidence interval ranging from 302 to 1997 ml. The data are summarized in nomograms covering 8 to 43 weeks' gestation.
本研究的目的是对整个妊娠期羊水体积的变化进行定量描述。从705篇已发表的正常妊娠羊水体积数据中，我们发现经对数转换后，妊娠8至43周期间羊水体积具有均匀的变异性。因此，95%置信区间涵盖了任何给定孕周平均体积的1/2.57至2.57倍范围。与预期趋势相反，妊娠22至39周期间羊水平均体积无显著变化，平均为777毫升，95%置信区间为302至1997毫升。数据总结在涵盖妊娠8至43周的列线图中。
