Colley M H, Geppert E, Franklin W A
Department of Pathology, University of Chicago, Illinois 60637.
Am J Surg Pathol. 1989 Sep;13(9):803-7. doi: 10.1097/00000478-198909000-00011.
Abnormal proliferation of smooth muscle cells in pulmonary lymphangioleiomyomatosis (LAM) is thought to be influenced by estrogen and progesterone. However, the results of previous studies using cytosolic methods to measure estrogen and progesterone receptor content in lung tissue from these patients have been inconsistent. We used immunohistochemical methods to study the tissue distribution of estrogen and progesterone receptors in LAM as well as in smooth muscle of several other organs, including histologically normal lung, colon, bladder, prostate, uterus, and uterine leiomyomas. Progesterone receptor was expressed strongly and estrogen receptor more weakly by the abnormal myoid cells of LAM. Hormone receptors were absent from all other constituents of lung tissue in our patient. These findings were similar to those in histologically normal myometrium and uterine leiomyomas. Although we found focal labeling of prostatic stromal cells with anti-progesterone receptor, no other smooth muscle tissue expressed either estrogen or progesterone receptor. We conclude that LAM is an abnormal proliferation of smooth muscle cells that express both estrogen and progesterone receptors.
肺淋巴管平滑肌瘤病（LAM）中平滑肌细胞的异常增殖被认为受雌激素和孕激素影响。然而，以往使用胞质方法测量这些患者肺组织中雌激素和孕激素受体含量的研究结果并不一致。我们采用免疫组化方法研究LAM以及其他几个器官平滑肌中雌激素和孕激素受体的组织分布，这些器官包括组织学正常的肺、结肠、膀胱、前列腺、子宫和平滑肌瘤。LAM的异常肌样细胞强烈表达孕激素受体，雌激素受体表达较弱。我们患者肺组织的所有其他成分均未检测到激素受体。这些发现与组织学正常的子宫肌层和平滑肌瘤中的发现相似。虽然我们发现抗孕激素受体对前列腺基质细胞有局灶性标记，但其他平滑肌组织均未表达雌激素或孕激素受体。我们得出结论，LAM是一种同时表达雌激素和孕激素受体的平滑肌细胞异常增殖。
