Chaichanyut Montree, Tungjitkusolmun Supan
Department of Electronic Engineering, Faculty of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.
Comput Math Methods Med. 2016;2016:4846738. doi: 10.1155/2016/4846738. Epub 2016 Aug 24.
This research is concerned with microwave ablation analyses using a 2.45 GHz four-tine (4T) antenna for hepatic cancer tissue. In the study, three-dimensional finite-element models were utilized to examine the tissue temperature distributions during and after MW ablation. A preliminary study was first carried out with regard to the specific absorption rates along the 4T antenna insertion depths and the temperature distributions inside the solid and porous liver models with either 3 cm-in-diameter tumor or 5 cm-in-diameter tumor. Based on the preliminary results, the porous models were further examined for the effect of varying blood flow velocities (0-200 cm/s) with a 1 cm-in-diameter blood vessel next to the antenna and also for the effect of vessel-antenna locations (0, 0.8, and 1.3 cm) with a constant blood flow velocity of 16.7 cm/s. All scenarios were simulated under temperature-controlled mode (90°C). The findings revealed that the blood flow velocity and vessel location influence the ablation effectiveness and that increased blood flow inhibits heat transfer to the vessel wall. At the nearest and farthest vessel-antenna locations (0 and 1.3 cm), approximately 90.3% and 99.55% of the cancer cells were eradicated except for the areas adjacent to the vessel. In addition, total tissue thermal displacement is 5.9 mm which is 6.59% of the total length of the overall model.
本研究关注使用2.45 GHz四叉（4T）天线对肝癌组织进行微波消融分析。在该研究中，利用三维有限元模型来检查微波消融期间及之后的组织温度分布。首先针对沿4T天线插入深度的比吸收率以及直径为3 cm或5 cm肿瘤的实体和多孔肝脏模型内部的温度分布进行了初步研究。基于初步结果，进一步研究了多孔模型，考察了在天线旁有直径1 cm血管时不同血流速度（0 - 200 cm/s）的影响，以及在血流速度恒定为16.7 cm/s时血管与天线不同位置（0、0.8和1.3 cm）的影响。所有情况均在温度控制模式（90°C）下进行模拟。研究结果表明，血流速度和血管位置会影响消融效果，且血流增加会抑制向血管壁的热传递。在血管与天线最近和最远位置（0和1.3 cm），除了与血管相邻的区域外，约90.3%和99.55%的癌细胞被根除。此外，组织总热位移为5.9 mm，占整个模型总长度的6.59%。
