Tungjitkusolmun Supan, Staelin S Tyler, Haemmerich Dieter, Tsai J Z, Webster John G, Lee Fred T, Mahvi David M, Vorperian Vicken R
Department of Electronics Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
IEEE Trans Biomed Eng. 2002 Jan;49(1):3-9. doi: 10.1109/10.972834.
Radio-frequency (RF) hepatic ablation, offers an alternative method for the treatment of hepatic malignancies. We employed finite-element method (FEM) analysis to determine tissue temperature distribution during RF hepatic ablation. We constructed three-dimensional (3-D) thermal-electrical FEM models consisting of a four-tine RF probe, hepatic tissue, and a large blood vessel (10-mm diameter) located at different locations. We simulated our FEM analyses under temperature-controlled (90 degrees C) 8-min ablation. We also present a preliminary result from a simplified two-dimensional (2-D) FEM model that includes a bifurcated blood vessel. Lesion shapes created by the four-tine RF probe were mushroom-like, and were limited by the blood vessel. When the distance of the blood vessel was 5 mm from the nearest distal electrode 1) in the 3-D model, the maximum tissue temperature (hot spot) appeared next to electrodes A. The location of the hot spot was adjacent to another electrode 2) on the opposite side when the blood vessel was 1 mm from electrode A. The temperature distribution in the 2-D model was highly nonuniform due to the presence of the bifurcated blood vessel. Underdosed areas might be present next to the blood vessel from which the tumor can regenerate.
射频（RF）肝脏消融术为肝脏恶性肿瘤的治疗提供了一种替代方法。我们采用有限元法（FEM）分析来确定射频肝脏消融术中的组织温度分布。我们构建了三维（3-D）热电有限元模型，该模型由一个四叉射频探头、肝组织以及位于不同位置的一条大血管（直径10毫米）组成。我们在温度控制为90摄氏度的8分钟消融条件下模拟了有限元分析。我们还展示了一个简化的二维（2-D）有限元模型的初步结果，该模型包含一条分叉血管。四叉射频探头形成的病灶形状呈蘑菇状，并受血管限制。在3-D模型中，当血管距离最近的远端电极5毫米时，最高组织温度（热点）出现在电极A旁边。当血管距离电极A 1毫米时，热点位置在相对侧与另一个电极相邻。由于存在分叉血管，二维模型中的温度分布极不均匀。血管旁可能会出现剂量不足区域，肿瘤可能会从该区域再生
