Lyons E T, Drudge J H, Tolliver S C
Department of Veterinary Science, University of Kentucky, Lexington 40546-0099.
Am J Vet Res. 1989 Jun;50(6):975-7.
A controlled blind test was performed in 1984 to evaluate the anthelmintic activity of experimental formulations of compound F28249-alpha against gastrointestinal parasites in lambs in Kentucky. Twenty-five lambs were allotted to 5 groups of 5 lambs/group. The drug was administered SC to 2 groups (A, 0.2 mg/kg of body weight; B, 0.3 mg/kg) and orally to 2 groups (C, 0.2 mg/kg; D, 0.3 mg/kg). Group E received a placebo subcutaneously. Lambs were euthanatized 7 days after treatment for necropsy and identification and enumeration of worm parasites in the gastrointestinal tract. Group-E lambs harbored 7 genera (including 10 species) of nematodes and 1 genus of tapeworms. Worm collection data for group-A lambs indicated 97% to 100% of the mature Haemonchus, Ostertagia, Trichostrongylus, and Trichuris, and immature Haemonchus were removed; and 23% to 73% of the mature Cooperia, Nematodirus, and Strongyloides, and immature Nematodirus were removed. In group-B lambs, 94% to 100% of the mature Haemonchus, Nematodirus, Ostertagia, Trichostrongylus, and Trichuris, and immature Haemonchus were removed as were 70% to 84% of mature Strongyloides and immature Nematodirus, respectively, and 0% for mature Cooperia. The percentage of all nematodes removed in group C and D was 100%, except for Cooperia (95%) in group C and immature Nematodirus (93% and 95%), respectively. Toxicosis was not apparent. Small fibrotic or blood streaked lesions were observed at necropsy in muscle at the injection site of 2 lambs in group B and 1 lamb in group E.
1984年进行了一项对照盲法试验，以评估化合物F28249-α的实验制剂对肯塔基州羔羊胃肠道寄生虫的驱虫活性。25只羔羊被分成5组，每组5只。药物以皮下注射方式给予2组（A组，0.2mg/kg体重；B组，0.3mg/kg），口服给予2组（C组，0.2mg/kg；D组，0.3mg/kg）。E组皮下注射安慰剂。治疗7天后对羔羊实施安乐死以进行尸检，并识别和计数胃肠道内的蠕虫寄生虫。E组羔羊体内有7个线虫属（包括10个物种）和1个绦虫属。A组羔羊的蠕虫收集数据表明，97%至100%的成熟血矛线虫、奥斯特他线虫、毛圆线虫和鞭虫以及未成熟血矛线虫被清除；23%至73%的成熟库珀线虫、细颈线虫和类圆线虫以及未成熟细颈线虫被清除。在B组羔羊中，94%至100%的成熟血矛线虫、细颈线虫、奥斯特他线虫、毛圆线虫和鞭虫以及未成熟血矛线虫被清除，成熟类圆线虫和未成熟细颈线虫分别有70%至84%被清除，成熟库珀线虫的清除率为0%。C组和D组所有线虫的清除率均为100%，C组的库珀线虫除外（95%），D组未成熟细颈线虫的清除率分别为93%和95%。未观察到明显的中毒症状。在尸检时，B组的2只羔羊和E组的1只羔羊在注射部位的肌肉中观察到小的纤维化或有血丝的病变。
