Walter P
Augenklinik, RWTH Aachen.
Klin Monbl Augenheilkd. 2016 Nov;233(11):1238-1243. doi: 10.1055/s-0042-115411. Epub 2016 Sep 19.
Implantable retinal prostheses for the blind are already in use. In blind subjects suffering from retinitis pigmentosa (RP), these systems are able to induce phosphenes. However, the measurable gain in vision is limited. This is due to degeneration in the retina itself and to the technology, which is used in the currently available systems. Research groups and companies are working on solutions and prototypes to improve the outcome of electrical stimulation in the visual system. One improvement will be to enlarge the electrode array in order to restore a larger visual field. A second approach is to enlarge the number of electrodes and to place them at a higher density to improve the spatial resolution of the system. A third concept is to develop a recording unit within the electrode array to analyse ganglion cell behaviour underneath the electrode. This information can than be used to optimise the stimulation pattern. Not only retinal prostheses are under development but also systems to stimulate the retina from the suprachoroidal space, to directly stimulate the optic nerve or the lateral geniculate body or even the primary visual cortex.
用于盲人的可植入视网膜假体已经在使用。在患有视网膜色素变性(RP)的盲人受试者中,这些系统能够诱发光幻视。然而,可测量的视力改善是有限的。这是由于视网膜本身的退化以及当前可用系统中所使用的技术。研究团队和公司正在致力于解决方案和原型,以改善视觉系统中电刺激的效果。一项改进是扩大电极阵列,以恢复更大的视野。第二种方法是增加电极数量并以更高的密度放置它们,以提高系统的空间分辨率。第三个概念是在电极阵列内开发一个记录单元,以分析电极下方神经节细胞的行为。然后这些信息可用于优化刺激模式。不仅视网膜假体正在研发中,而且还有从脉络膜上腔刺激视网膜、直接刺激视神经或外侧膝状体甚至初级视觉皮层的系统。