Funakoshi Yasuhiro, Harada Masafumi, Otsuka Hideki, Mori Kenji, Ito Hiromichi, Iwanaga Takashi
Department of Medical Imaging, Institute of Biomedical Sciences, University of Tokushima Graduate School.
J Med Invest. 2016;63(3-4):204-8. doi: 10.2152/jmi.63.204.
The purpose of this study was to investigate changes in the functional connectivity of the default mode network (DMN) in normal aging and in children with autistic spectrum disorder (ASD) by using resting-state functional magnetic resonance imaging (rsfMRI) and independent component analysis.
Thirty-one healthy controls (HC) in four age groups (1-3, 4-8, 20-29, and 50-59 years) and 14 childhood ASD cases (1-8 years of age) were examined by rsfMRI echo-planar imaging on a clinical 3-T MRI scanner. Imaging of all children (1-8 years) was conducted under sedation, while adults were scanned in the awake state with eyes closed.
The regions of DMN functional connectivity in the bilateral inferior parietal lobule and posterior cingulate cortex were smaller in HC children than in HC adults, and smaller in the ASD group than in the HC children.
It is possible to observe developmental and pathological changes in the DMN by rsfMRI. Reduced DMN functional connectivity in children may be a useful biomarker for ASD diagnosis. J. Med. Invest. 63: 204-208, August, 2016.
本研究旨在通过静息态功能磁共振成像（rsfMRI）和独立成分分析，调查正常衰老以及自闭症谱系障碍（ASD）儿童默认模式网络（DMN）功能连接性的变化。
在临床3-T MRI扫描仪上，采用rsfMRI回波平面成像技术对四个年龄组（1-3岁、4-8岁、20-29岁和50-59岁）的31名健康对照者（HC）以及14例儿童ASD患者（1-8岁）进行检查。所有儿童（1-8岁）在镇静状态下成像，而成人在清醒且闭眼状态下进行扫描。
双侧下顶叶小叶和后扣带回皮质中DMN功能连接的区域在HC儿童中比在HC成人中更小，且在ASD组中比在HC儿童中更小。
通过rsfMRI可以观察到DMN的发育和病理变化。儿童DMN功能连接性降低可能是ASD诊断的一个有用生物标志物。《医学调查杂志》63: 204-208，2016年8月。
