Adnan Khosravi, Esfahani-Monfared Zahra, Sei Sharareh, Karimi Shirin, Emami Habib, Khodadad Kian
Medical Oncology, Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran E-mail :
Asian Pac J Cancer Prev. 2016;17(8):3817-22.
Lung cancer has long been a leading cause of cancer related death in both women and men worldwide. The focus of this study was to review clinicopathological features of Iranian patients diagnosed with lung cancer.
Clinicopathological data of 1353 primary lung cancer patients diagnosed during 17 years (1997-2014) in the "National Institute of Tuberculosis and Lung Disease" (NRITLD), Tehran, Iran, were retrospectively reviewed.
The median age of patients was 60 (mean: 58.95 years, range: 16- 99) and adenocarcinoma was the most prevalent pathology (45.2%). Male/female ratio was 3.22 and 57.2% of patients were smokers (men 70.3%, women 15%). The majority (85.3%) were referred in advanced stages (stage IIIB and IV).
Although some of our findings are in concordance with other studies in lung cancer there are some discrepancies particularly in terms of smoking status and median age of Iranian patients. Further clinical and epidemiological studies are warranted to elucidate etiologic and factors other than smoking contributing to development of lung cancer, such as environmental exposures or genetic predisposition.
长期以来，肺癌一直是全球男性和女性癌症相关死亡的主要原因。本研究的重点是回顾伊朗肺癌患者的临床病理特征。
回顾性分析了1997年至2014年期间在伊朗德黑兰“国家结核病和肺部疾病研究所”（NRITLD）确诊的1353例原发性肺癌患者的临床病理资料。
患者的中位年龄为60岁（平均：58.95岁，范围：16 - 99岁），腺癌是最常见的病理类型（45.2%）。男女比例为3.22，57.2%的患者为吸烟者（男性70.3%，女性15%）。大多数患者（85.3%）在晚期（IIIB期和IV期）就诊。
虽然我们的一些发现与其他肺癌研究一致，但也存在一些差异，特别是在伊朗患者的吸烟状况和中位年龄方面。有必要进行进一步的临床和流行病学研究，以阐明除吸烟外导致肺癌发生的病因和其他因素，如环境暴露或遗传易感性。
