Friedhoff F W, Atamer M A, Thelmo W L
Chemotherapy. 1978;24(5):321-6. doi: 10.1159/000237799.
The clinical course of a patient with chronic granulocytic leukemia cutis associated with myeloid metaplasia is described. Cutaneous manifestations of leukemia appeared only at the sites of bone marrow aspiration and vena puncture. Radiotherapy to both spleen and skin and chemotherapy with busulfan failed to control spreading cutaneous lesions. Treatment with hydroxyurea was followed by a marked reduction in spleen size, a decrease in white cell count and healing of the skin lesions.
描述了一名慢性粒细胞性白血病皮肤病变合并骨髓化生患者的临床病程。白血病的皮肤表现仅出现在骨髓穿刺和静脉穿刺部位。对脾脏和皮肤进行放疗以及使用白消安化疗均未能控制皮肤病变的扩散。使用羟基脲治疗后，脾脏大小显著缩小，白细胞计数降低，皮肤病变愈合。
