Brunner Thomas B, Seufferlein Thomas
Department of Radiation Oncology, University Medical Center Freiburg, Robert-Koch-Str. 3, Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Internal Medicine I, Ulm University, Albert-Einstein-Allee 23, D-89081, Ulm, Germany.
Best Pract Res Clin Gastroenterol. 2016 Aug;30(4):617-28. doi: 10.1016/j.bpg.2016.08.001. Epub 2016 Aug 20.
Pancreatic cancer is the most lethal gastrointestinal tumour. Chemotherapy is the mainstay of therapy in the majority of the patients whereas resection is the only chance of cure but only possible in 15-20% of all patients. The integration of radiotherapy into multimodal treatment concepts is heavily investigated. It is now commonly accepted that induction chemotherapy should precede radiotherapy. When fractionated conventionally it should be given as chemoradiotherapy. Recently, stereotactic body radiotherapy emerged as an alternative, but will have to be carefully investigated in clinical trials. This review aims to give an overview of radiotherapeutic strategies with a focus on the latest developments in the field in the context of chemotherapy and surgery.
胰腺癌是最致命的胃肠道肿瘤。化疗是大多数患者的主要治疗方法，而手术切除是唯一的治愈机会，但仅适用于所有患者中的15%至20%。放疗在多模式治疗理念中的整合正在深入研究。目前普遍认为诱导化疗应在放疗之前进行。传统分割放疗时应采用放化疗。最近，立体定向体部放疗作为一种替代方法出现，但必须在临床试验中进行仔细研究。本综述旨在概述放射治疗策略，重点关注该领域在化疗和手术背景下的最新进展。
