胎盘 ABC 转运体：生物学影响与药物学意义。
Placental ABC Transporters: Biological Impact and Pharmaceutical Significance.
机构信息
Department of Pharmaceutics, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia, 23298-0533, USA.
Novartis Institutes of Biomedical Research, Cambridge, Massachusetts, USA.
出版信息
Pharm Res. 2016 Dec;33(12):2847-2878. doi: 10.1007/s11095-016-2028-8. Epub 2016 Sep 19.
Abstract
The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.
摘要
人类胎盘在产前生活中发挥着多种重要功能。几种 ABC 转运体在人胎盘表达，在转运内源性化合物中发挥作用，并可能保护胎儿免受外源性化合物（如治疗药物、滥用药物和其他异源生物）的侵害。迄今为止，人们在理解胎盘 ABC 转运体方面已经取得了相当大的进展。本文讨论了 ABC 转运体亚家族 B、C 和 G 的几个成员的表达和功能活性的最新研究，包括 MDR1/P-糖蛋白、MRPs 和 BCRP。由于胎盘 ABC 转运体调节胎儿对各种化合物的暴露，因此了解其功能和调节机制将有助于在妊娠期间必要时更合理地使用药物。
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