Division of Neurology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Division of Neurology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; Bumrungrad International Hospital, Bangkok 10110, Thailand.
Mult Scler Relat Disord. 2016 Sep;9:14-6. doi: 10.1016/j.msard.2016.06.006. Epub 2016 Jun 11.
A few reports studied the time use to diagnose patient with neuromyelitis optica (NMO). The Aim of the study is to evaluate the interval from disease onset to the time when patients fulfilled the NMO diagnostic criteria 2006 in Thai.
A retrospective study of the NMO patients visiting the MS clinic and related disorders at Siriraj hospital was reviewed.
There were 42 definite NMO. All were female. The most common first presentations were optic neuritis (ON) (45.2%), transverse myelitis (TM) (35.7%), ON and TM (9.5%) and brainstem symptoms (9.5%), respectively. The mean age at onset of their ON and TM attack was 33.4 and 38.4 years, respectively. Anti-AQP4 antibody was presented in 82% using cell based assay. For those presented with ON, 7.1% reported painful eye movements and 33.3% had bilateral involvement. Brain MRI not compatible with MS was found in 94.87%. In who presented with TM, 87.8% revealed long extensive transverse myelitis (LETM) in spinal MRI. The presence of CSF-oligoclonal band (CSF-OCB) was found in 14.6%. Our NMO patients had the average number of the attack of 1.5 times before the diagnosis could be made. Nearly fifty-five percent of NMO patients fulfilled the NMO diagnostic criteria 2006 within 1 year after disease onset and 90.5% within 5 years
About half of Thai patients with definite NMO were diagnosed within 1 year and approximately 90% within 5 years from their disease onset.
有一些研究报告分析了视神经脊髓炎（NMO）患者的诊断时间。本研究旨在评估泰国患者从发病到满足 2006 年 NMO 诊断标准的时间间隔。
回顾性分析了在 Siriraj 医院 MS 诊所及相关疾病就诊的 NMO 患者。
共纳入 42 例确诊的 NMO 患者，均为女性。最常见的首发症状为视神经炎（ON）（45.2%）、横贯性脊髓炎（TM）（35.7%）、ON 和 TM（9.5%）和脑干症状（9.5%）。ON 和 TM 发作的平均发病年龄分别为 33.4 岁和 38.4 岁。使用基于细胞的检测方法，82%的患者抗 AQP4 抗体阳性。对于表现为 ON 的患者，7.1%报告有痛性眼球运动，33.3%有双侧受累。94.87%的患者脑 MRI 不符合 MS 表现。TM 患者中，87.8%的脊髓 MRI 显示长节段横贯性脊髓炎（LETM）。14.6%的患者存在 CSF-寡克隆带（CSF-OCB）。我们的 NMO 患者在确诊前的平均发作次数为 1.5 次。近 55%的 NMO 患者在发病后 1 年内满足 2006 年 NMO 诊断标准，90.5%在 5 年内满足。
约一半的泰国确诊 NMO 患者在发病后 1 年内、约 90%在 5 年内被诊断。
