西班牙穆尔西亚第三卫生区多发性硬化症的流行情况。

Prevalence of multiple sclerosis in Health District III, Murcia, Spain.

机构信息

Section of Neurology, Hospital Rafael Méndez, Lorca, Spain.

Health Centre "Lorca Centro", Lorca, Spain.

出版信息

Mult Scler Relat Disord. 2016 Sep;9:31-5. doi: 10.1016/j.msard.2016.06.003. Epub 2016 Jun 8.

DOI:10.1016/j.msard.2016.06.003

PMID:27645340

Abstract

BACKGROUND

The prevalence of multiple sclerosis (MS) varies throughout the world, and available epidemiological data suggest a progressively increasing prevalence of MS in Spain. The objective of this study was to calculate MS prevalence in Health District III of the autonomous community of Murcia in Spain.

METHODS

This is an observational, cross-sectional, descriptive study. The prevalence of MS in Health District III in the Region of Murcia, which includes the municipalities of Lorca, Totana, Águilas, Puerto Lumbreras and Aledo, was calculated from the total population (171,040 inhabitants), and among native Spanish citizens only (137,659 persons). Healthcare and demographic data were obtained from three sources: 1) OMI-AP: the local primary care computer system containing the medical records of all subscribers; 2) the medical record database of the Hospital Rafael Mendez (the single hospital in the district); and 3) the records of the AEMA III Multiple Sclerosis Association to which patients from this healthcare district belong. Data from these three sources were combined to check the accuracy and completeness of the patient records.

RESULTS

The prevalence of MS among the general population of this district, including non-Spanish individuals, was 71.9 per 100,000 inhabitants (95% CI=60-85). Prevalence among the native Spanish population was 82.0 per 100,000 (95% CI=68-98). Considering prevalence by sex, it was 118.1 per 100,000 (95% CI: 95-146) in the female native Spanish population, and 45.4 per 100,000 (95% CI: 31-64) in the male native Spanish population. The prevalence in the native Spanish population in this district was calculated by sex and age (grouped by decades). A peak was observed among women aged between 20 and 29 years: 234.2 per 100,000 inhabitants (95% CI: 151-361).

CONCLUSION

Our results suggest that the population in this healthcare district presents a risk of MS similar to that recently reported in other regions of Spain, which is higher than in previous decades.

摘要

背景

多发性硬化症（MS）的患病率在全球范围内存在差异，现有的流行病学数据表明，西班牙的 MS 患病率呈逐渐上升趋势。本研究的目的是计算西班牙穆尔西亚自治区第三卫生区的 MS 患病率。

方法

这是一项观察性、横断面、描述性研究。通过对穆尔西亚地区第三卫生区（包括洛尔卡、托塔纳、阿吉拉斯、波多黎各卢姆布拉雷斯和阿莱多市）的总人口（171040 人）和西班牙本地公民（137659 人）进行计算，得出了该地区 MS 的患病率。从三个来源获取医疗保健和人口统计数据：1）OMI-AP：包含所有订阅者医疗记录的本地初级保健计算机系统；2）该地区唯一医院拉斐尔·门德斯医院（Hospital Rafael Mendez）的病历数据库；3）AEMA III 多发性硬化症协会的记录，该协会的患者来自该医疗区。将这三个来源的数据合并，以检查患者记录的准确性和完整性。

结果

该地区总人口（包括非西班牙人）的 MS 患病率为 71.9/100000 人（95%CI=60-85）。西班牙本地人口的患病率为 82.0/100000 人（95%CI=68-98）。按性别考虑患病率，西班牙本地女性的患病率为 118.1/100000 人（95%CI：95-146），西班牙本地男性的患病率为 45.4/100000 人（95%CI：31-64）。通过性别和年龄（按十年分组）计算了该地区西班牙本地人口的患病率。在 20-29 岁的女性中患病率达到峰值：234.2/100000 人（95%CI：151-361）。