Department of Neurology, Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Tevfik Saglam Cad No:25/2, 34147 Bakirkoy, Istanbul, Turkey.
Department of Nephrology, Bakirkoy Dr Sadi Konuk Reasaerch and Training Hospital, Tevfik Saglam Street No:11, 34147 Bakirkoy, Istanbul, Turkey.
Mult Scler Relat Disord. 2016 Sep;9:50-3. doi: 10.1016/j.msard.2016.06.012. Epub 2016 Jun 27.
Interferon beta (IFN β) subtypes are largely used as immunomodulatory agents in Multiple Sclerosis (MS) treatment. While being generally well tolerated, they can cause various side effects. Adverse effects related to kidney are rarely reported.
We report a 32 years old male patient who developed nephrotic syndrome while receiving IFN β for MS. Biopsy showed focal segmental glomerulosclerosis. He went into remisson after cessation of drug and with the aid of angiotensin II antagonists. Here, we report this case and a review of similar cases reported in literature.
Although it's a rare adverse effect and tend to show good prognosis physicians should pay careful attention to symptoms and findings of nephropathy during follow ups of patients under treatment with these agents.
干扰素 β（IFN β）亚型在多发性硬化症（MS）治疗中主要用作免疫调节剂。虽然通常耐受性良好，但它们可能会引起各种副作用。与肾脏相关的不良反应很少见报道。
我们报告了一名 32 岁男性患者，他在接受 IFN β 治疗 MS 时发生了肾病综合征。活检显示局灶节段性肾小球硬化症。他在停药和血管紧张素 II 拮抗剂的帮助下进入缓解期。在这里，我们报告了这个病例，并回顾了文献中报道的类似病例。
虽然这是一种罕见的不良反应，且往往预后良好，但医生在随访接受这些药物治疗的患者时，应密切注意肾病的症状和发现。
