Nehme and Therese Tohme Multiple Sclerosis Center, Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon.
Nehme and Therese Tohme Multiple Sclerosis Center, Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon.
Mult Scler Relat Disord. 2016 Sep;9:122-4. doi: 10.1016/j.msard.2016.07.012. Epub 2016 Jul 25.
Natalizumab was the first FDA-approved monoclonal antibody for the treatment of multiple sclerosis (MS). We report on 3 natalizumab-treated patients who developed herpes zoster infections. In addition to progressive multifocal leukoencephelopathy, other opportunistic infections have been rarely reported during Natalizumab treatment. We believe that clinicians need heightened awareness of these infections in view of the risks of serious complications.
那他珠单抗是首个获美国食品药品监督管理局批准用于治疗多发性硬化症 (MS) 的单克隆抗体。我们报告了 3 例那他珠单抗治疗后发生带状疱疹感染的患者。除了进行性多灶性白质脑病，在那他珠单抗治疗期间还很少有其他机会性感染的报道。鉴于严重并发症的风险，我们认为临床医生需要提高对这些感染的认识。
