纳塔昔珠单抗治疗多发性硬化症患者的淋巴细胞谱改变和带状疱疹感染。
Altered lymphocyte profiles and herpes zoster infections in patients with multiple sclerosis on natalizumab.
机构信息
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
出版信息
Mult Scler. 2024 Sep;30(10):1370-1373. doi: 10.1177/13524585241260537. Epub 2024 Jun 16.
Cases of herpes zoster (HZ) in patients with MS on natalizumab (NTZ) have been documented. In this study, we assessed lymphocyte subsets in NTZ-treated patients with HZ compared to matched controls without HZ. Twenty unvaccinated patients developed HZ while on NTZ for an incidence rate of 12.3 per 1000 patient-years. These patients had lower CD8+% and higher CD4+:CD8+ ratios ( ⩽ 0.01) than non-HZ matched controls. Two patients with relapsing-remitting MS developed HZ twice while on NTZ. These findings underscore the importance of pre-NTZ HZ vaccination due to potential HZ risk.
已有报道称，在接受那他珠单抗（NTZ）治疗的多发性硬化症（MS）患者中出现了带状疱疹（HZ）病例。在这项研究中，我们评估了与未发生 HZ 的匹配对照组相比，在接受 NTZ 治疗的 HZ 患者中的淋巴细胞亚群。在接受 NTZ 治疗期间，有 20 名未接种疫苗的患者发生 HZ，HZ 发生率为每 1000 患者年 12.3 例。与未发生 HZ 的匹配对照组相比，这些患者的 CD8+%较低，CD4+:CD8+比值较高（ ⩽ 0.01）。两名复发性缓解型 MS 患者在接受 NTZ 治疗期间发生了两次 HZ。这些发现强调了在接受 NTZ 治疗前进行 HZ 疫苗接种的重要性，因为存在潜在的 HZ 风险。
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