巴西多发性硬化症、视神经脊髓炎和脊髓炎患者的乳糜泻血清流行率。
Serological prevalence of celiac disease in Brazilian population of multiple sclerosis, neuromyelitis optica and myelitis.
机构信息
Medical neurologist, Department of Neurology, Sarah Network of Rehabilitation Hospitals, SMHS Quadra 501 Conj. A, Brasilia, DF 70.330-150 Brazil.
Medical geneticist, Department of Genetics, Sarah Network of Rehabilitation Hospitals, Brasilia, Brazil.
出版信息
Mult Scler Relat Disord. 2016 Sep;9:125-8. doi: 10.1016/j.msard.2016.07.018. Epub 2016 Jul 26.
PURPOSE
Comorbidity of celiac disease with demyelinating diseases of the central nervous system has been reported since the 1960s. The objective of this study was to determine the serological prevalence of celiac disease in the largest series of patients diagnosed with multiple sclerosis, neuromyelitis optica, or myelitis.
METHODS
A prevalence study was conducted with patients evaluated at Sarah Network of Rehabilitation Hospitals between March 2012 and September 2013. They were previously diagnosed with multiple sclerosis, neuromyelitis optica, or idiopathic myelitis. The serum levels of antibodies against tissue transglutaminase and endomysium were assessed.
RESULTS
Of the 379 patients evaluated, 249 (65.70%) were diagnosed with multiple sclerosis, 37 (9.56%) with neuromyelitis optica, and 96 (24.54%) with idiopathic myelitis. Two patients (0.53%), one with multiple sclerosis and other with myelitis, tested positive for both antibodies.
CONCLUSION
Our study do not confirm the relationship between celiac serological antibodies with multiple sclerosis, neuromyelitis optica and inflammatory myelitis of an unknown etiology.
目的
自 20 世纪 60 年代以来，已有文献报道乳糜泻与中枢神经系统脱髓鞘疾病并存。本研究的目的是确定在最大系列多发性硬化症、视神经脊髓炎或脊髓炎患者中乳糜泻的血清患病率。
方法
对 2012 年 3 月至 2013 年 9 月在 Sarah 康复医院网络接受评估的患者进行了一项患病率研究。他们之前被诊断为多发性硬化症、视神经脊髓炎或特发性脊髓炎。评估了针对组织转谷氨酰胺酶和内肌层抗体的血清水平。
结果
在评估的 379 名患者中，249 名（65.70%）被诊断为多发性硬化症，37 名（9.56%）为视神经脊髓炎，96 名（24.54%）为特发性脊髓炎。两名患者（0.53%），一名多发性硬化症和另一名脊髓炎患者，两种抗体均呈阳性。
结论
我们的研究并未证实乳糜泻血清抗体与多发性硬化症、视神经脊髓炎和病因不明的炎症性脊髓炎之间存在关系。
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