Kroemer Alexander, Cosentino Christopher, Kaiser Jason, Matsumoto Cal S, Fishbein Thomas M
MedStar Georgetown Transplant Institute, 2PHC, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA.
Curr Gastroenterol Rep. 2016 Nov;18(11):56. doi: 10.1007/s11894-016-0530-0.
Intestinal transplantation is the most immunologically complex of all abdominal organ transplants. Understanding the role both humoral and innate and adaptive cellular immunity play in intestinal transplantation is critical to improving outcomes and increasing indications for patients suffering from intestinal failure. Recent findings highlighting the impact of donor-specific antibodies on intestinal allografts, the role of NOD2 as a key regulator of intestinal immunity, the protective effects of innate lymphoid cells, and the role of Th17 in acute cellular rejection are reviewed here.
肠道移植是所有腹部器官移植中免疫复杂性最高的。了解体液免疫、固有免疫和适应性细胞免疫在肠道移植中所起的作用，对于改善患有肠衰竭患者的治疗效果和扩大适应症至关重要。本文综述了近期的研究发现，这些发现突出了供体特异性抗体对肠道同种异体移植物的影响、NOD2作为肠道免疫关键调节因子的作用、固有淋巴细胞的保护作用以及Th17在急性细胞排斥反应中的作用。
