Lopes Patricia C
Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
Inflammopharmacology. 2016 Oct;24(5):291-293. doi: 10.1007/s10787-016-0283-2. Epub 2016 Sep 19.
Lipopolysaccharide (LPS) administration has been repeatedly shown to elicit central inflammation, regardless of the route of administration. In a recent study, Tiwari et al. (Inflammopharmacology 10.1007/s10787-016-0274-3 , 2016) dispute the potential of peripheral administration of LPS to induce neuroinflammation. Here, I summarise literature indicating that the neuroinflammatory effects of LPS are time dependent, and suggest that their findings can be explained by the time at which they chose to measure neuroinflammation.
无论给药途径如何，脂多糖（LPS）给药已被反复证明会引发中枢炎症。在最近的一项研究中，蒂瓦里等人（《炎症药理学》10.1007/s10787-016-0274-3，2016年）对经外周给予LPS诱导神经炎症的可能性提出了质疑。在此，我总结了表明LPS的神经炎症作用具有时间依赖性的文献，并认为他们的研究结果可以通过他们选择测量神经炎症的时间来解释。
