脂质体包裹的全氟己烷在不额外供氧的情况下增强小鼠放疗效果。
Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply.
作者信息
Xu Linfeng, Qiu Xuefeng, Zhang Yanting, Cao Kai, Zhao Xiaozhi, Wu Jinhui, Hu Yiqiao, Guo Hongqian
机构信息
Department of Uroloågy, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China.
State Key Laboratory of Pharmaceutical Biotechnology, School of Medicine, Nanjing University, Nanjing, 210093, China.
出版信息
J Transl Med. 2016 Sep 20;14:268. doi: 10.1186/s12967-016-1033-3.
BACKGROUND
To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)].
METHODS
After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent accumulation in tumor 24 h post injection. X-ray was delivered to the tumor site 24 h after the injection of lip(PFH) under room air. The experimental mice were randomized into four groups: control (saline), lip(PFH) (lip(PFH) only), X-ray (X-ray only), and lip(PFH) + X-ray (lip(PFH) with X-ray radiation). Tumor volume and histology were monitored to assess treatment efficacy.
RESULTS
Tumor growth was significantly reduced in mice received lip(PFH) and X-ray compared with X-ray only. The histological data also revealed more destruction of tumor tissue in lip(PFH) + X-ray group compared with X-ray only. In addition, lip(PFH) did not show any significant tissue damage to major organs or induce significant liver/kidney dysfunction.
CONCLUSIONS
Lip(PFH) could accumulate in the tumor site and enhance radiotherapy without additional oxygen supply.
背景
为研究全氟化合物制剂在增强放射治疗方面的作用，通过将全氟己烷包裹于脂质体中制备了全氟碳纳米粒[脂质体包裹全氟己烷（lip(PFH)）]。
方法
静脉注射后，lip(PFH)可随时间在肿瘤部位蓄积，注射后24小时在肿瘤内有显著蓄积。在室内空气中注射lip(PFH) 24小时后对肿瘤部位进行X线照射。将实验小鼠随机分为四组：对照组（生理盐水）、lip(PFH)组（仅lip(PFH)）、X线组（仅X线）和lip(PFH)+X线组（lip(PFH)联合X线照射）。监测肿瘤体积和组织学情况以评估治疗效果。
结果
与仅接受X线照射的小鼠相比，接受lip(PFH)和X线照射的小鼠肿瘤生长显著减缓。组织学数据还显示，与仅接受X线照射组相比，lip(PFH)+X线组肿瘤组织破坏更严重。此外，lip(PFH)对主要器官未显示出任何明显的组织损伤，也未诱导显著的肝/肾功能障碍。
结论
Lip(PFH)可在肿瘤部位蓄积并增强放射治疗效果，且无需额外供氧。
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