Waghe Prashantkumar, Sarkar Souvendra Nath, Sarath Thengumpallil Sasindran, Kandasamy Kannan, Choudhury Soumen, Gupta Priyanka, Harikumar Sankarankutty, Mishra Santosh Kumar
Department of Veterinary Pharmacology and Toxicology, Veterinary College, Vinobanagar, Shimoga, Karnataka, 577 204, India.
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
Biol Trace Elem Res. 2017 Apr;176(2):350-354. doi: 10.1007/s12011-016-0851-8. Epub 2016 Sep 19.
Arsenic is a groundwater pollutant and can cause various cardiovascular disorders in the exposed population. The aim of the present study was to assess whether subchronic arsenic exposure through drinking water can induce vascular dysfunction associated with alteration in plasma electrolytes and lipid profile. Rats were exposed to arsenic as 25, 50, and 100 ppm of sodium arsenite through drinking water for 90 consecutive days. On the 91st day, rats were sacrificed and blood was collected. Lipid profile and the levels of electrolytes (sodium, potassium, and chloride) were assessed in plasma. Arsenic reduced high-density lipoprotein cholesterol (HDL-C) and HDL-C/LDL-C ratio, but increased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and electrolytes. The results suggest that the arsenic-mediated dyslipidemia and electrolyte retention could be important mechanisms in the arsenic-induced vascular disorder.
砷是一种地下水污染物，可使接触人群出现各种心血管疾病。本研究的目的是评估通过饮用水进行亚慢性砷暴露是否会导致与血浆电解质和血脂谱改变相关的血管功能障碍。大鼠连续90天通过饮用水接触浓度为25、50和100 ppm的亚砷酸钠。在第91天，处死大鼠并采集血液。评估血浆中的血脂谱和电解质（钠、钾和氯）水平。砷降低了高密度脂蛋白胆固醇（HDL-C）和HDL-C/LDL-C比值，但增加了甘油三酯、总胆固醇、低密度脂蛋白胆固醇（LDL-C）和电解质的水平。结果表明，砷介导的血脂异常和电解质潴留可能是砷诱导血管疾病的重要机制。
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