Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, No.1 Zhiyuan Road, Guangxi, 541199, Guilin, China.
Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guangxi, 541199, Guilin, China.
Lipids Health Dis. 2022 Dec 6;21(1):131. doi: 10.1186/s12944-022-01743-6.
Exposure to heavy metals in the environment is widespread, while the relationship between combined exposure to heavy metals and dyslipidemia is unclear.
A cross-sectional study was performed, and 3544 participants aged 30 years or older were included in the analyses. Heavy metal concentrations in plasma were based on inductively coupled plasma‒mass spectrometry. The relationship between heavy metals and dyslipidemia was estimated by logistic regression. BKMR was used to evaluate metal mixtures and their potential interactions.
In logistic regression analysis, participants in the fourth quartile of Fe and Zn (Fe > 1352.38 µg/L; Zn > 4401.42 µg/L) had a relatively higher risk of dyslipidemia (Fe, OR = 1.13, 95% CI: 0.92,1.38; Zn, OR = 1.30, 95% CI: 1.03,1.64). After sex stratification, females in the third quartile of plasma Zn (1062.05-4401.42 µg/L) had a higher relative risk of dyslipidemia (OR = 1.75, 95% CI: 1.28, 2.38). In BKMR analysis, metal mixtures were negatively associated with dyslipidemia in females when all metal concentrations were above the 50th percentile. In the total population (estimated from 0.030 to 0.031), As was positively associated with dyslipidemia when other metals were controlled at the 25th, 50th, or 75th percentile, respectively, and As was below the 75th percentile. In females (estimated from - 0.037 to -0.031), Zn was negatively associated with dyslipidemia when it was above the 50th percentile.
This study indicated that As was positively associated with dyslipidemia and that Zn may be negatively associated with dyslipidemia in females. Combined metal exposure was negatively associated with dyslipidemia in females. Females with low plasma Zn levels are more likely to develop dyslipidemia and should receive more clinical attention in this population.
环境中重金属的暴露很普遍，而重金属联合暴露与血脂异常的关系尚不清楚。
进行了一项横断面研究，纳入了 3544 名年龄在 30 岁及以上的参与者。基于电感耦合等离子体质谱法检测血浆中的重金属浓度。采用 logistic 回归估计重金属与血脂异常的关系。BKMR 用于评估金属混合物及其潜在相互作用。
在 logistic 回归分析中，Fe 和 Zn 第 4 四分位数（Fe>1352.38µg/L；Zn>4401.42µg/L）的参与者血脂异常的相对风险较高（Fe，OR=1.13，95%CI：0.92，1.38；Zn，OR=1.30，95%CI：1.03，1.64）。经性别分层后，血浆 Zn 第 3 四分位数（1062.05-4401.42µg/L）的女性血脂异常的相对风险较高（OR=1.75，95%CI：1.28，2.38）。在 BKMR 分析中，当所有金属浓度均高于第 50 百分位数时，女性金属混合物与血脂异常呈负相关。在总人群中（估计值为 0.030 至 0.031），当其他金属分别控制在第 25、50 和 75 百分位数时，As 与血脂异常呈正相关，而当 As 低于第 75 百分位数时，As 与血脂异常呈正相关。在女性中（估计值为-0.037 至-0.031），当 Zn 高于第 50 百分位数时，Zn 与血脂异常呈负相关。
本研究表明，As 与血脂异常呈正相关，而 Zn 可能与女性血脂异常呈负相关。联合金属暴露与女性血脂异常呈负相关。血浆 Zn 水平较低的女性更有可能发生血脂异常，在该人群中应给予更多的临床关注。
