[家族性和散发性强直性脊柱炎中补体的功能异常]

[Functional abnormalities of complement in familial and sporadic ankylosing spondylitis].

作者信息

Jiménez Balderas F J, Rico Rosillo G, Bravo Gatica C, Mintz Spiro G

出版信息

Arch Invest Med (Mex). 1989 Jan-Mar;20(1):79-86.

Abstract

Levels of complement fractions of 12 patients with sporadic ankylosing Spondylitis and 6 patients with familial Ankylosing Spondylitis (N. Y. Criteria) were studied by an hemolytic and functional method (microhemolysis in plate. Cordis Lab. Miami, Fla. USA). Abnormal levels were found in 94% of them high levels of C1 and C2 (p 0.002), and C3 (p 0.05) C8 and C9 (p 0.001) deficiencies, mixed or isolated, correlated with the severity of the diseases. C9 deficiency belongs to familial Ankylosing Spondylitis. These functional deficiencies of serum complement can favor the colonization and persistence of germs, which could mediate in the genesis of Ankylosing Spondylitis.

摘要

采用溶血和功能检测方法（美国佛罗里达州迈阿密科迪斯实验室的平板微量溶血法），对12例散发性强直性脊柱炎患者和6例家族性强直性脊柱炎患者（纽约标准）的补体成分水平进行了研究。结果发现，94%的患者存在异常水平，C1和C2水平升高（p<0.002），C3水平升高（p<0.05），C8和C9缺乏（p<0.001），这些缺乏情况可为混合性或孤立性，且与疾病严重程度相关。C9缺乏见于家族性强直性脊柱炎。血清补体的这些功能缺陷可能有利于细菌的定植和持续存在，进而可能在强直性脊柱炎的发病机制中起作用。