Zhao Xiaohua, Liu Jingjing, Zhao Cuisheng, Ye Ping, Ji Jing, Wang Jingli, Song Weiqing, Xu Jine, Liu Shiguo
a Clinical Laboratory , Linyi People's Hospital , Linyi , China.
b Department of Blood Transfusion , The Affiliated Hospital of Qingdao University , Qingdao , China.
Hypertens Pregnancy. 2016 Nov;35(4):565-572. doi: 10.1080/10641955.2016.1211677. Epub 2016 Sep 19.
Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women.
A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR .
No significant difference in the genotypic and allelic distribution was found between the two groups (genotype: X = 0.583, p = 0.747; allele:X = 0.526, p = 0.468).
The COMT Val158Met polymorphism might not be associated with PE in Chinese women.
既往研究表明，儿茶酚-O-甲基转移酶基因（COMT）可能在子痫前期（PE）的发生发展中起重要作用。本研究旨在探讨中国汉族女性中COMT基因多态性与PE易感性之间的关联。
共纳入1028例PE患者和1399例正常孕妇。采用TaqMan等位基因鉴别实时荧光定量PCR法检测COMT Val158Met位点的基因分型。
两组间基因型和等位基因分布无显著差异（基因型：X = 0.583，p = 0.747；等位基因：X = 0.526，p = 0.468）。
COMT Val158Met基因多态性可能与中国女性的PE无关。
