中国汉族人群中儿茶酚-O-甲基转移酶（COMT）Val158Met基因多态性与子痫前期的关联
Association between COMT Val158Met polymorphism and preeclampsia in the Chinese Han population.
作者信息
Zhao Xiaohua, Liu Jingjing, Zhao Cuisheng, Ye Ping, Ji Jing, Wang Jingli, Song Weiqing, Xu Jine, Liu Shiguo
机构信息
a Clinical Laboratory , Linyi People's Hospital , Linyi , China.
b Department of Blood Transfusion , The Affiliated Hospital of Qingdao University , Qingdao , China.
出版信息
Hypertens Pregnancy. 2016 Nov;35(4):565-572. doi: 10.1080/10641955.2016.1211677. Epub 2016 Sep 19.
OBJECTIVE
Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women.
METHOD
A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR .
RESULTS
No significant difference in the genotypic and allelic distribution was found between the two groups (genotype: X = 0.583, p = 0.747; allele:X = 0.526, p = 0.468).
CONCLUSION
The COMT Val158Met polymorphism might not be associated with PE in Chinese women.
目的
既往研究表明，儿茶酚-O-甲基转移酶基因（COMT）可能在子痫前期（PE）的发生发展中起重要作用。本研究旨在探讨中国汉族女性中COMT基因多态性与PE易感性之间的关联。
方法
共纳入1028例PE患者和1399例正常孕妇。采用TaqMan等位基因鉴别实时荧光定量PCR法检测COMT Val158Met位点的基因分型。
结果
两组间基因型和等位基因分布无显著差异（基因型：X = 0.583，p = 0.747；等位基因：X = 0.526，p = 0.468）。
结论
COMT Val158Met基因多态性可能与中国女性的PE无关。
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