Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
Org Lett. 2016 Oct 7;18(19):5010-5013. doi: 10.1021/acs.orglett.6b02469. Epub 2016 Sep 20.
A novel synthetic approach for the synthesis of bioactive phenolic natural products is reported. This strategy highlights the power of halogenative aromatization reactions recently developed in our group for preparing densely functionalized arenes in a controlled fashion. Five natural products related by an aromatic core and a farnesyl side chain are synthesized. In contrast to prior methods, this synthesis features high efficiency and generality that permits preparation of targets in gram-scale quantities.
本文报道了一种新颖的合成生物活性酚类天然产物的方法。该策略突出了我们小组最近开发的卤代芳烃化反应在以可控方式制备稠合多官能芳烃方面的强大功能。合成了五个具有芳香核和法呢基侧链的天然产物。与以前的方法相比，该合成具有高效率和通用性，可在克级规模制备目标产物。
