Khan Muhammad Saim, Basit Imran, Ishaq Mazhar, Shakoor Tariq, Yaqub Amer, Intisar Rana
Dr. Muhammad Saim Khan, MBBS. Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan.
Dr. Imran Basit, FCPS, FRCS (G). Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan.
Pak J Med Sci. 2016 Jul-Aug;32(4):965-8. doi: 10.12669/pjms.324.10138.
To determine mean change in visual acuity, central corneal thickness and symptoms in patients with pseudophakic bullous keratopathy after treatment with corneal collagen crosslinking.
This quasi experimental study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from April 2015 to Nov 2015. A total of 24 eyes of 24 patients were included in the study. Visual symptoms were graded in five grades (Grade 1-5), Grade-1 being very mild with decreased vision only while patients with all five symptoms (decreased vision, foreign body sensations, pain, watering and photophobia) were graded as Grade-5. Corneal collagen cross linking using topical isotonic riboflavin followed by UVA radiations (3mW/cm(2) for 10 minutes) was performed in all the patients. Visual acuity (VA), visual symptoms and central corneal thickness (CCT) were recorded before and 04 weeks after the treatment.
A total of 24 eyes of 24 patients (18 male and 6 females) underwent surgery. Age of the patients ranged from 55 to 75 years with mean age 65.83 + 3.89 years. Mean visual acuity was 2.09 + 0.23 before treatment while after treatment it was 2.13 + 0.22. Mean CCT as measured by optical pachymetry (Galilae G6) was 753.96 + 55.16 and 641+ 29.25 before and after surgery respectively. Improvement of clinical symptoms was seen in all the patients.
Corneal collagen cross linking is a temporary but effective symptomatic treatment of pseudophakic bullous keratopathy.
确定角膜胶原交联治疗后，人工晶状体眼大泡性角膜病变患者的视力、中央角膜厚度及症状的平均变化。
本准实验研究于2015年4月至2015年11月在巴基斯坦拉瓦尔品第武装部队眼科研究所进行。共纳入24例患者的24只眼。视觉症状分为五个等级（1 - 5级），1级为非常轻微，仅视力下降，而具有所有五种症状（视力下降、异物感、疼痛、流泪和畏光）的患者被评为5级。所有患者均采用局部等渗核黄素然后进行紫外线A辐射（3mW/cm²，持续10分钟）的角膜胶原交联治疗。记录治疗前及治疗后4周的视力（VA）、视觉症状和中央角膜厚度（CCT）。
24例患者（18例男性和6例女性）的24只眼接受了手术。患者年龄在55至75岁之间，平均年龄为65.83 ± 3.89岁。治疗前平均视力为2.09 ± 0.23，治疗后为2.13 ± 0.22。术前及术后分别采用光学角膜厚度测量仪（Galilae G6）测量的平均CCT为753.96 ± 55.16和641 ± 29.25。所有患者的临床症状均有改善。
角膜胶原交联是人工晶状体眼大泡性角膜病变的一种临时但有效的对症治疗方法。
