交联对角膜水肿患者角膜厚度的影响。

Effect of cross-linking on corneal thickness in patients with corneal edema.

机构信息

Cornea and External Diseases Division, Instituto da Visão, Federal University of Sao Paulo, Sao Paulo, Brazil.

出版信息

Cornea. 2010 Jun;29(6):613-7. doi: 10.1097/ICO.0b013e3181c296c2.

DOI:10.1097/ICO.0b013e3181c296c2

PMID:20458230

Abstract

PURPOSE

To investigate the pachymetric changes of collagen cross-linking in corneas with edema because of endothelial dysfunction.

METHODS

Interventional case series included 25 eyes of 25 consecutive patients with corneal edema for at least 4 months related to Fuchs endothelial dystrophy, corneal graft failure, and postoperative bullous keratopathy. Central corneal thickness was measured preoperatively, 1, 3, and 6 months after the procedure by ultrasound pachymetry and optical coherence tomography.

RESULTS

Mean central corneal thickness measured by ultrasound pachymetry decreased after corneal cross-linking (mean +/- SD): 712.0 +/- 99.7, 618.3 +/- 103.0, and 657.5 +/- 114.8 for preoperative, 1-, and 3-month follow-up, respectively. Differences between preoperative value and 1- and 3-month follow-up values were statistically significant (P < 0.01). Similar results were found with the optical coherence tomography (mean +/- SD): 777.3 +/- 131.0, 711.6 +/- 133.1, 746.4 +/- 142.4, and 830.6 +/- 198.7, for preoperative, 1-, 3-, and 6-month follow-up values, respectively. Fourteen patients (56%) developed new epithelial bullae after 3 months; 11 patients (44%) remained asymptomatic until their last visit.

CONCLUSION

Corneal cross-linking showed to be a safe procedure and potential therapeutic alternative for the treatment of corneal edema.

摘要

目的

研究因内皮功能障碍导致水肿的角膜胶原交联的厚度变化。

方法

本研究为一项干预性病例系列研究，纳入了 25 例 25 只眼的患者，这些患者的角膜水肿至少持续 4 个月，其病因包括 Fuchs 内皮营养不良、角膜移植失败和术后大泡性角膜病变。所有患者均于术前、术后 1、3 和 6 个月采用超声角膜测厚仪和光学相干断层扫描仪测量中央角膜厚度。

结果

超声角膜测厚仪测量的平均中央角膜厚度在角膜交联术后（平均值 ± 标准差）分别为：术前为 712.0 ± 99.7μm，术后 1 个月为 618.3 ± 103.0μm，术后 3 个月为 657.5 ± 114.8μm。术前值与术后 1 个月和 3 个月随访值之间的差异具有统计学意义（P < 0.01）。光学相干断层扫描仪也得到了相似的结果（平均值 ± 标准差）：术前为 777.3 ± 131.0μm，术后 1 个月为 711.6 ± 133.1μm，术后 3 个月为 746.4 ± 142.4μm，术后 6 个月为 830.6 ± 198.7μm。术后 3 个月，有 14 名患者（56%）出现新的上皮水疱；11 名患者（44%）在最后一次就诊时仍无症状。