两种角膜胶原交联方法治疗富克斯内皮营养不良所致大疱性角膜病变的疗效
Outcome of Two Corneal Collagen Crosslinking Methods in Bullous Keratopathy due to Fuchs' Endothelial Dystrophy.
作者信息
Ucakhan Omur O, Saglik Ayhan
机构信息
Department of Ophthalmology, Ankara University Faculty of Medicine, Mamak Caddesi, Cebeci, 06340 Ankara, Turkey.
出版信息
Case Rep Med. 2014;2014:463905. doi: 10.1155/2014/463905. Epub 2014 Nov 17.
Four eyes of 2 patients with corneal edema due to Fuchs' endothelial dystrophy were treated with CXL using the standard protocol. Since no improvement in visual acuity, corneal clarity, thickness, or pain sensation was evident in any eye at month 12, 2 eyes of the 2 patients were retreated, this time, following intraoperative corneal dehydration with glycerol 70% drops. This retreatment also failed to produce any significant effect on vision, corneal clarity, thickness, or pain in either eye. Collagen crosslinking with the current protocols may not be effective in the management of eyes with corneal edema due to Fuchs' endothelial dystrophy. Further studies are required to establish the efficacy of CXL and optimize the technique and/or dehydration method utilized in these cases.
对2例因富克斯内皮营养不良导致角膜水肿患者的4只眼睛采用标准方案进行了角膜交联术治疗。由于在第12个月时，任何一只眼睛的视力、角膜清晰度、厚度或疼痛感均无明显改善，因此对这2例患者的2只眼睛进行了再次治疗，此次是在术中用70%甘油滴眼液进行角膜脱水后进行的。再次治疗对任何一只眼睛的视力、角膜清晰度、厚度或疼痛也均未产生任何显著效果。采用当前方案的胶原交联术可能对治疗因富克斯内皮营养不良导致角膜水肿的眼睛无效。需要进一步研究以确定角膜交联术的疗效，并优化这些病例中所采用的技术和/或脱水方法。
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