Ruprecht K, Tumani H
Klinik für Neurologie, Klinisches und Experimentelles Forschungszentrum für Multiple Sklerose, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
Fachklinik für Neurologie Dietenbronn, Dietenbronn 7, 88477, Schwendi, Deutschland.
Nervenarzt. 2016 Dec;87(12):1282-1287. doi: 10.1007/s00115-016-0220-z.
As a chronic inflammatory disease of the central nervous system (CNS), multiple sclerosis (MS) is associated with characteristic abnormalities in cerebrospinal fluid (CSF). Thus, in addition to magnetic resonance imaging, CSF examination is a central diagnostic procedure in patients with MS, which can corroborate a diagnosis of MS and may also help to discern differential diagnoses. The most important CSF finding in MS is the detection of persistent polyspecific intrathecal immunoglobulin synthesis. This review summarizes CSF findings of patients with MS and addresses issues of relevance for clinical practice, potential diagnostic pitfalls as well as new developments in CSF diagnostics of MS.
作为一种中枢神经系统（CNS）的慢性炎症性疾病，多发性硬化症（MS）与脑脊液（CSF）中的特征性异常有关。因此，除了磁共振成像外，CSF检查是MS患者的一项核心诊断程序，它可以证实MS的诊断，也有助于鉴别诊断。MS最重要的CSF发现是持续性多特异性鞘内免疫球蛋白合成的检测。本综述总结了MS患者的CSF检查结果，并讨论了与临床实践相关的问题、潜在的诊断陷阱以及MS患者CSF诊断的新进展。
