Institute of Biochemistry, Graz University of Technology, Petersgasse 12/2, A-8010 Graz, Austria.
Institute of Biochemistry, Graz University of Technology, Petersgasse 12/2, A-8010 Graz, Austria.
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jan;1862(1):25-38. doi: 10.1016/j.bbalip.2016.09.007. Epub 2016 Sep 17.
Phosphatidylethanolamine is one of the most abundant phospholipids whose major amounts are formed by phosphatidylserine decarboxylases (PSD). Here we provide a comprehensive description of different types of PSDs in the different kingdoms of life. In eukaryotes, type I PSDs are mitochondrial enzymes, whereas other PSDs are localized to other cellular compartments. We describe the role of mitochondrial Psd1 proteins, their function, enzymology, biogenesis, assembly into mitochondria and their contribution to phospholipid homeostasis in much detail. We also discuss briefly the cellular physiology and the enzymology of Psd2. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
磷脂酰乙醇胺是最丰富的磷脂之一，其主要部分由磷脂酰丝氨酸脱羧酶（PSD）形成。在这里，我们提供了对生命不同领域中不同类型 PSD 的全面描述。在真核生物中，I 型 PSD 是线粒体酶，而其他 PSD 则定位于其他细胞区室。我们详细描述了线粒体 Psd1 蛋白的作用、功能、酶学、生物发生、组装到线粒体中以及它们对磷脂稳态的贡献。我们还简要讨论了 Psd2 的细胞生理学和酶学。本文是由 Guenther Daum 编辑的题为“线粒体的脂质”的特刊的一部分。
