Májovský M, Netuka D, Beneš V
Rozhl Chir. 2016 fall;95(8):305-11.
The pineal region is a deep-seated part of the brain surrounded by highly eloquent structures. Differential diagnosis of space-occupying lesions in this region encompasses pineal gland cysts, pineal gland tumours, metastases, germ cell tumours, meningiomas, gliomas, hemangioblastomas and neuroectodermal tumours. A treatment strategy is based mainly on tumour anatomical characteristics and histological type. Except germinatous tumours, a surgical excision is the treatment of choice.
Microsurgical approaches: The microsurgical supracerebellar-infratentorial approach is an essential approach to the pineal region. Despite certain risks, it allows a straightforward and completely extracerebral approach with a minimal cerebellar retraction. The other basic approach is the microsurgical occipital-transtentorial approach that is advantageous in patients with a supratentorial tumour extension or a steep tentorium. The interhemispheric-transcallosal approach and the transcortical-transventricular approach are possible options in selected cases.Endoscopic approaches: The neuroendoscopy provides a minimally invasive method to perform a tumour biopsy and to treat hydrocephalus in one session. Stereotactic biopsy: The stereotactic needle biopsy represents an alternative to the endoscopic biopsy in patients without hydrocephalus and in patients with dorsally located lesions inaccessible from the third ventricle.
Modern neurosurgery offers a rich variety of surgical approaches to the pineal region. The complexity of space-occupying lesions in this region requires an individualised treatment, a prudent preoperative planning and a meticulous surgical technique.
松果体区是大脑的一个深部区域,周围环绕着功能高度明确的结构。该区域占位性病变的鉴别诊断包括松果体囊肿、松果体肿瘤、转移瘤、生殖细胞肿瘤、脑膜瘤、胶质瘤、成血管细胞瘤和神经外胚层肿瘤。治疗策略主要基于肿瘤的解剖特征和组织学类型。除生殖细胞瘤外,手术切除是首选治疗方法。
显微手术入路:显微手术小脑上-幕下入路是松果体区的重要入路。尽管存在一定风险,但它允许采用直接且完全在脑外的入路,小脑牵拉最小。另一种基本入路是显微手术枕下-经幕入路,对于幕上肿瘤扩展或天幕陡峭的患者具有优势。在特定病例中,半球间-经胼胝体入路和经皮质-经脑室入路也是可行的选择。内镜入路:神经内镜提供了一种微创方法,可在一次手术中进行肿瘤活检并治疗脑积水。立体定向活检:对于没有脑积水且病变位于背侧无法从第三脑室进入的患者,立体定向针吸活检是内镜活检的替代方法。
现代神经外科为松果体区提供了丰富多样的手术入路。该区域占位性病变的复杂性需要个体化治疗、谨慎的术前规划和细致的手术技术。