Amoozgar Hamid, Zeighami Samaneh, Haghpanah Sezaneh, Karimi Mehran
a Neonatology and Cardiovascular Research Center , Shiraz University of Medical Sciences , Shiraz , Iran.
b Department of Pediatrics, School of Medicine , Shiraz University of Medical Sciences , Shiraz , Iran.
Hematology. 2017 Jan;22(1):25-29. doi: 10.1080/10245332.2016.1226699. Epub 2016 Sep 20.
The goal of this study was to compare heart function and arrhythmia in clinically asymptomatic patients with beta thalassemia intermedia and beta thalassemia major.
In this cross-sectional study, 60 patients with beta thalassemia major and 60 patients with beta thalassemia intermedia who had clinically no symptoms of arrhythmia and clinically normal heart function were evaluated using 24-hour ambulatory electrocardiogram monitoring and echocardiography. For data analysis SPSS ver.20 software was used. A P-value of less than 0.05 was considered statistically significant.
The mean age of the beta thalassemia intermedia patients was 24.18 ± 7.9 years and the mean age in beta thalassemia major was 24.38 ± 7.7 years (P>0.05). Premature atrial contractions (PACs) were observed in 14 (23.3%) patients with beta thalassemia intermedia and in 22 (36.6%) beta thalassemia major patients. Premature ventricular contractions (PVCs) were detected in 8 (13.3%) patients in the beta thalassemia intermediate group and 16 (26.6) patients in the beta thalassemia major group, respectively. The left ventricular diastolic dimension, end-diastolic volume, and stroke volume were significantly higher in beta thalassemia intermedia group (P<0.05). Pulmonary acceleration time as an indicator of pulmonary pressure was lower in beta thalassemia intermedia group.
Both atrial and ventricular arrhythmias were more common in the beta thalassemia major group. Higher end-diastolic volume and stroke volume were detected in the beta thalassemia intermedia group. Pulmonary acceleration time was lower in the beta thalassemia intermedia group, which can be an indicator of higher pulmonary pressure.
本研究的目的是比较中间型β地中海贫血和重型β地中海贫血临床无症状患者的心脏功能和心律失常情况。
在这项横断面研究中，对60例重型β地中海贫血患者和60例中间型β地中海贫血患者进行了评估，这些患者临床上没有心律失常症状且心脏功能正常，采用24小时动态心电图监测和超声心动图检查。数据分析使用SPSS 20.0软件。P值小于0.05被认为具有统计学意义。
中间型β地中海贫血患者的平均年龄为24.18±7.9岁，重型β地中海贫血患者的平均年龄为24.38±7.7岁（P>0.05）。14例（23.3%）中间型β地中海贫血患者和22例（36.6%）重型β地中海贫血患者出现房性早搏（PACs）。中间型β地中海贫血组8例（13.3%）患者和重型β地中海贫血组16例（26.6%）患者分别检测到室性早搏（PVCs）。中间型β地中海贫血组的左心室舒张末期内径、舒张末期容积和每搏输出量显著更高（P<0.05）。作为肺压力指标的肺动脉加速时间在中间型β地中海贫血组较低。
重型β地中海贫血组房性和室性心律失常更为常见。中间型β地中海贫血组检测到更高的舒张末期容积和每搏输出量。中间型β地中海贫血组的肺动脉加速时间较低，这可能是肺压力较高的一个指标。
