三苯基硼催化的叔酰胺的选择性还原胺化反应。
Chemoselective Reduction of Tertiary Amides to Amines Catalyzed by Triphenylborane.
机构信息
Institut für Anorganische Chemie, RWTH Aachen University, Landoltweg 1, 52056, Aachen, Germany.
Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan.
出版信息
Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13326-13329. doi: 10.1002/anie.201605236.
Triphenylborane (BPh ) was found to catalyze the reduction of tertiary amides with hydrosilanes to give amines under mild condition with high chemoselectivity in the presence of ketones, esters, and imines. N,N-Dimethylacrylamide was reduced to provide the α-silyl amide. Preliminary studies indicate that the hydrosilylation catalyzed by BPh may be mechanistically different from that catalyzed by the more electrophilic B(C F ) .
三苯基硼（BPh ）被发现可在温和条件下催化硅氢烷还原叔酰胺，在酮、酯和亚胺存在下具有高化学选择性得到胺。N,N-二甲基丙烯酰胺被还原为提供α-硅基酰胺。初步研究表明，BPh 催化的硅氢化反应可能在机理上不同于更亲电的 B(C F ) 催化的硅氢化反应。
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