Xiao Zhen, Li Juanjuan, Yue Qiang, Zhang Qian, Li Dong
School of Materials and Chemical Engineering, Hubei University of Technology Wuhan 430068 China
Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology Jingmen 448000 China.
RSC Adv. 2018 Oct 5;8(60):34304-34308. doi: 10.1039/c8ra07355d. eCollection 2018 Oct 4.
In this paper we reported a novel method for generation of -aryl amino alcohols from ,-disubstituted picolinamides through reduction/ring-opening reaction with NaBH. The ,-disubstituted picolinamides can be easily obtained from primary amines after convenient condensation with picolinic acid and coupling with cyclic ethers. The whole route proceeded under simple and mild conditions with high efficiency. Picolinic acid can be recovered in the form of piconol after reaction. It indicated an efficient and atom-economical route for the preparation of -aryl amino alcohols from primary amines.
在本文中，我们报道了一种通过与硼氢化钠进行还原/开环反应，从α,β-二取代吡啶酰胺生成α-芳基氨基醇的新方法。α,β-二取代吡啶酰胺可通过伯胺与吡啶甲酸方便地缩合并与环醚偶联后轻松获得。整个路线在简单温和的条件下高效进行。反应后吡啶甲酸可以皮考诺醇的形式回收。这表明从伯胺制备α-芳基氨基醇是一条高效且原子经济的路线。
