[代谢综合征增加2型糖尿病患者的弗雷明汉风险评分]
[Metabolic syndrome increases Framingham risk score of patients with type 2 diabetes mellitus].
作者信息
Meifang Yao, Xue Sun, Jue Han, Yina T U, Jie H E, Yiming Zhao, Hanyu Lou, Xiaohong Pang, Wenheng Zeng, Songzhao Zhang, Pengfei Shan
机构信息
Department of Endocrinology and Metabolism, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China;Health Management Center, Zhejiang Hospital, Hangzhou 310013, China.
Department of Endocrinology and Metabolism, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2016 May 25;45(3):268-74. doi: 10.3785/j.issn.1008-9292.2016.05.08.
OBJECTIVE
To assess the impact of metabolic syndrome(MS) on Framingham risk score(FRS) in patients with type 2 diabetes mellitus (T2DM).
METHODS
The anthropometric and biochemical data of 1708 patients with T2DM admitted in hospital from May 2008 to April 2013 were retrospectively analyzed, including 902 males and 806 females with a mean age of 57.1±11.8 years (20-79 years). Diagnosis of MS was made according to the criteria of the Adult Treatment Panel Ⅲ Criteria modified for Asians.
RESULTS
Compared to non-MS/T2DM patients, MS/T2DM patients had higher waist circumference, body weight, body mass index, systolic and diastolic blood pressure, fasting C peptide, total cholesterol, triglyceride, and LDL-C (P<0.05), while lower HDL-C (P<0.01). Both FRS [13.0(10.0, 15.0) vs 11.0(9.0, 13.0) in male,15.0(12.0, 18.0) vs 12.0(6.0, 14.8) in female,P<0.01)] and 10-year cardiovascular risk [12.0%(6.0%, 20.0%) vs 8.0%(5.0%,12.0%) in male,3.0%(1.0%, 6.0%) vs 1.0%(0.0%, 2.8%) in female,P<0.01] were higher in MS/T2DM patients than those in non-MS/T2DM patients.Both FRS and 10-year cardiovascular risk were increased with the components of MS.
CONCLUSION
T2DM patients with MS have more cardiovascular risk factors, higher FRS and 10-year cardiovascular risk.
目的
评估代谢综合征（MS）对2型糖尿病（T2DM）患者弗雷明汉风险评分（FRS）的影响。
方法
回顾性分析2008年5月至2013年4月期间收治的1708例T2DM患者的人体测量和生化数据，其中男性902例，女性806例，平均年龄57.1±11.8岁（20 - 79岁）。MS的诊断依据针对亚洲人修改后的成人治疗小组Ⅲ标准。
结果
与非MS/T2DM患者相比，MS/T2DM患者的腰围、体重、体重指数、收缩压和舒张压、空腹C肽、总胆固醇、甘油三酯和低密度脂蛋白胆固醇更高（P<0.05），而高密度脂蛋白胆固醇更低（P<0.01）。MS/T2DM患者的FRS[男性为13.0（10.0，15.0）对11.0（9.0，13.0），女性为15.0（12.0，18.0）对12.0（6.0，14.8），P<0.01]和10年心血管风险[男性为12.0%（6.0%，20.0%）对8.0%（5.0%，12.0%），女性为3.0%（1.0%，6.0%）对1.0%（0.0%，2.8%），P<0.01]均高于非MS/T2DM患者。FRS和10年心血管风险均随MS组分的增加而升高。
结论
合并MS的T2DM患者有更多心血管危险因素、更高的FRS和10年心血管风险。
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