脑内注射干细胞可抑制大鼠复发性酒精摄取行为
Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats.
作者信息
Israel Yedy, Ezquer Fernando, Quintanilla María Elena, Morales Paola, Ezquer Marcelo, Herrera-Marschitz Mario
机构信息
Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
出版信息
Alcohol Alcohol. 2017 Jan;52(1):1-4. doi: 10.1093/alcalc/agw068. Epub 2016 Sep 20.
Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats consumed alcohol for 3 months and were subjected to repeated alcohol deprivations for 7-14 days, followed by alcohol reaccess. Upon reaccess, animals consumed 2.2 g alcohol/kg in 60 minutes. A single intra-cerebroventricular MSC administration inhibited relapse-like drinking up to 80-85% for 40 days (P < 0.001). An alcohol-use-disorder was prevented.
研究描述了间充质干细胞（MSCs）对复发性酒精饮用的阻断作用。高酒精摄入量的繁殖大鼠连续3个月摄入酒精，并经历7至14天的反复酒精剥夺，随后再次接触酒精。再次接触酒精后，动物在60分钟内摄入2.2克酒精/千克。单次脑室内给予间充质干细胞可在40天内将复发性饮酒抑制高达80 - 85%（P < 0.001）。酒精使用障碍得到了预防。
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