Nissinen A, Pekkanen J, Porath A, Punsar S, Karvonen M J
National Public Health Institute, Helsinki, Finland.
Ann Med. 1989 Jun;21(3):239-40. doi: 10.3109/07853898909149943.
The importance of serum total cholesterol, systolic blood pressure, and smoking as predictors of cardiovascular (CVD) disease were studied in 867 men aged 55 to 74 years belonging to the Finnish cohorts of the Seven Countries Study. Men had no definite history of myocardial infarction nor any signs of cerebrovascular disease at baseline in 1974. During the 10-year follow-up 248 men either died from CVD or had non-fatal CVD event, including a total of 188 fatal and nonfatal coronary heart disease (CHD) events. Age-adjusted relative risk of CVD event for men aged 55 to 64 with cholesterol over 7.4 mmol/l compared to below 6.0 mmol/l was 2.6, with systolic blood pressure over 159 mmHg vs. below 135 mmHg 1.8, and smoking over 19 cigarettes per day vs. never smoker 1.7. Corresponding relative risks for men aged 65 to 74 were 1.0, 1.4 and 1.2, respectively. The results for CHD events were closely similar. The results indicate that, in terms of relative risk, systolic blood pressure retains its importance as risk factor for CVD and CHD from late middle age to old age, whereas the importance of smoking is diminished, and serum cholesterol is of little importance in old age.
在七国研究的芬兰队列中，对867名年龄在55至74岁之间的男性进行了研究，以探讨血清总胆固醇、收缩压和吸烟作为心血管疾病（CVD）预测指标的重要性。在1974年基线时，这些男性没有明确的心肌梗死病史，也没有任何脑血管疾病的迹象。在10年的随访期间，248名男性死于CVD或发生了非致命性CVD事件，其中包括总共188例致命和非致命性冠心病（CHD）事件。55至64岁男性中，胆固醇超过7.4 mmol/l与低于6.0 mmol/l相比，年龄调整后的CVD事件相对风险为2.6；收缩压超过159 mmHg与低于135 mmHg相比为1.8；每天吸烟超过19支与从不吸烟者相比为1.7。65至74岁男性的相应相对风险分别为1.0、1.4和1.2。CHD事件的结果非常相似。结果表明，就相对风险而言，从中年后期到老年，收缩压作为CVD和CHD的危险因素仍然很重要，而吸烟的重要性降低，血清胆固醇在老年时重要性不大。
