心脏移植患者的高血压与动脉僵硬度
Hypertension and arterial stiffness in heart transplantation patients.
作者信息
de Souza-Neto João David, de Oliveira Ĺtalo Martins, Lima-Rocha Hermano Alexandre, Oliveira-Lima José Wellington, Bacal Fernando
机构信息
Hospital de Messejana Dr. Carlos Alberto Studart Gomes, Unidade de Transplante e Insuficiência Cardíaca, Fortaleza/CE, Brazil.
Universidade Federal do Ceará, Departamento de Saúde Comunitária, Fortaleza/CE, Brazil.
出版信息
Clinics (Sao Paulo). 2016 Sep;71(9):494-9. doi: 10.6061/clinics/2016(09)02.
OBJECTIVES
Post-transplantation hypertension is prevalent and is associated with increased cardiovascular morbidity and subsequent graft dysfunction. The present study aimed to identify the factors associated with arterial stiffness as measured by the ambulatory arterial stiffness index.
METHODS
The current study used a prospective, observational, analytical design to evaluate a group of adult heart transplantation patients. Arterial stiffness was obtained by monitoring ambulatory blood pressure and using the ambulatory arterial stiffness index as the surrogate outcome. Multivariate logistic regression analyses were performed to control confounding.
RESULTS
In a group of 85 adult heart transplantation patients, hypertension was independently associated with arterial stiffness (OR 4.98, CI 95% 1.06-23.4) as well as systolic and diastolic blood pressure averages and nighttime descent.
CONCLUSIONS
Measurement of ambulatory arterial stiffness index is a new, non-invasive method that is easy to perform, may contribute to better defining arterial stiffness prognosis and is associated with hypertension.
目的
移植后高血压很常见，且与心血管疾病发病率增加及随后的移植物功能障碍相关。本研究旨在确定与动态动脉僵硬度指数所测量的动脉僵硬度相关的因素。
方法
本研究采用前瞻性、观察性、分析性设计来评估一组成年心脏移植患者。通过监测动态血压并使用动态动脉僵硬度指数作为替代结局来获取动脉僵硬度。进行多因素逻辑回归分析以控制混杂因素。
结果
在一组85名成年心脏移植患者中，高血压与动脉僵硬度（比值比4.98，95%置信区间1.06 - 23.4）以及收缩压和舒张压平均值及夜间血压下降独立相关。
结论
动态动脉僵硬度指数测量是一种新的、非侵入性的方法，操作简便，可能有助于更好地界定动脉僵硬度预后，且与高血压相关。
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