Hypertension Center, 3rd Department of Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki bPediatric Intensive Care Unit, Hippokration Hospital, Thessaloniki, Greece.
J Hypertens. 2011 Oct;29(10):1847-53. doi: 10.1097/HJH.0b013e32834a4d9f.
Vascular aging is described as a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modification of the signals that modulate them. On the basis of this conception a new pathophysiological model for deeper understanding of cardiovascular risk and its treatment was introduced. The idea of early vascular aging, that is the acceleration of vascular aging seems to be a promising tool for clinical guidance in individuals at increased cardiovascular risk or a strong family history of early cardiovascular manifestations. Increased arterial stiffness, dilation of central elastic arteries, impaired endothelial function and vasodilatation are dominant aspects of this premature process.
血管老化被描述为一个涉及血管的生化、酶和细胞变化以及调节这些变化的信号修饰的渐进过程。基于这一概念，引入了一种新的病理生理模型，以更深入地了解心血管风险及其治疗。早期血管老化的概念，即血管老化的加速，似乎是一种有前途的工具，可以为心血管风险增加或有早期心血管表现家族史的个体提供临床指导。动脉僵硬度增加、中央弹性动脉扩张、内皮功能和血管舒张受损是这一早期过程的主要方面。
