Dzieża-Grudnik Anna, Sulicka Joanna, Strach Magdalena, Siga Olga, Klimek Ewa, Korkosz Mariusz, Grodzicki Tomasz
a Department of Internal Medicine and Gerontology , Jagiellonian University Medical College , Krakow , Poland.
b Department of Rheumatology and Balneology , Jagiellonian University Medical College , Krakow , Poland.
Blood Press. 2017 Apr;26(2):115-121. doi: 10.1080/08037051.2016.1232586. Epub 2016 Sep 22.
Patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have increased cardiovascular (CV) morbidity and mortality. Arterial stiffness is an independent predictor of CV events. The aim of the study was to assess arterial stiffness and inflammatory markers in patients with short duration chronic arthritis. We assessed carotid-femoral pulse wave velocity (PWV), augmentation index (AIx), traditional CV risk factors and inflammatory and endothelial markers in 71 chronic arthritis patients (RA and AS) and in 29 healthy controls. We did not find differences in PWV (for RA, AS and controls, respectively: 10 [8.8-10.9] versus 10.7 [9.1-11.8] versus 9.2 [8.3-11.4] m/s; p = .14) and AIx (for RA, AS and controls, respectively: 24.3 ± 11.5 versus 5.7 ± 12.4 versus 10 ± 12.8%; p = .22). Both groups of arthritis patients had active disease with significantly elevated inflammatory markers compared to controls. There were no correlations between endothelial and inflammatory markers and parameters of arterial stiffness in arthritis patients. When analyzing arthritis patients according to median of PVW, there were no significant differences in inflammatory and endothelial markers. We found that in patients with short duration active RA and AS arterial stiffness was not increased and furthermore, there was no association between markers of systemic inflammation and arterial stiffness.
类风湿关节炎（RA）和强直性脊柱炎（AS）患者的心血管（CV）发病率和死亡率有所增加。动脉僵硬度是CV事件的独立预测因子。本研究的目的是评估病程较短的慢性关节炎患者的动脉僵硬度和炎症标志物。我们评估了71例慢性关节炎患者（RA和AS）和29例健康对照者的颈股脉搏波速度（PWV）、增强指数（AIx）、传统CV危险因素以及炎症和内皮标志物。我们未发现PWV（RA、AS和对照组分别为：10[8.8 - 10.9]对10.7[9.1 - 11.8]对9.2[8.3 - 11.4]m/s；p = 0.14）和AIx（RA、AS和对照组分别为：24.3±11.5对5.7±12.4对10±12.8%；p = 0.22）存在差异。与对照组相比，两组关节炎患者均患有活动性疾病，炎症标志物显著升高。关节炎患者的内皮和炎症标志物与动脉僵硬度参数之间无相关性。根据PVW中位数分析关节炎患者时，炎症和内皮标志物无显著差异。我们发现，病程较短的活动性RA和AS患者的动脉僵硬度并未增加，此外，全身炎症标志物与动脉僵硬度之间也无关联。
