Jelinic Maria, Kahlberg Nicola, Parry Laura J, Tare Marianne
School of BioSciences, The University of Melbourne, Parkville, Victoria, Australia.
Department of Physiology, Monash University, Parkville, Victoria, Australia.
Microcirculation. 2016 Nov;23(8):631-636. doi: 10.1111/micc.12321.
The peptide hormone relaxin is recognized for its connective tissue remodeling actions in the reproductive tract during pregnancy and parturition, but it also has vascular remodeling actions independent of pregnancy. Recombinant human relaxin (serelaxin) treatment in male and non-pregnant female rodents enhances passive arterial compliance in the renal vasculature. This review focuses on serelaxin's actions on passive mechanical wall properties in small arteries and highlights the diversity of responses to serelaxin treatment in rodents. Different experimental approaches (duration of serelaxin treatment, rat strain, age) and animal models of disease (obesity, hypertension) will be considered. Most studies in young rodents demonstrate that serelaxin treatment fails to alter passive compliance in resistance-size arteries (mesenteric and femoral arteries and cerebral parenchymal arterioles), suggesting that serelaxin's beneficial effects are minimal in healthy animals. Short-term serelaxin treatment (5d) in aged, obese, and spontaneously hypertensive rats (SHRs) is largely without effect on passive mechanical wall properties. However, a longer duration of serelaxin treatment in SHRs (14d) enhances passive compliance in large muscular arteries as well as resistance-size arteries. In conclusion, serelaxin is capable of vascular remodeling. Its actions are vascular bed-dependent, more prominent in disease, and likely requires a longer duration of treatment to be effective.
肽类激素松弛素因其在妊娠和分娩期间对生殖道结缔组织重塑的作用而被人们所熟知，但它也具有独立于妊娠的血管重塑作用。在雄性和未怀孕雌性啮齿动物中进行重组人松弛素（serelaxin）治疗，可增强肾血管系统的被动动脉顺应性。本综述聚焦于serelaxin对小动脉被动机械壁特性的作用，并强调了啮齿动物对serelaxin治疗反应的多样性。我们将考虑不同的实验方法（serelaxin治疗持续时间、大鼠品系、年龄）和疾病动物模型（肥胖、高血压）。大多数针对年轻啮齿动物的研究表明，serelaxin治疗无法改变阻力大小动脉（肠系膜动脉、股动脉和脑实质小动脉）的被动顺应性，这表明在健康动物中，serelaxin的有益作用微乎其微。在老年、肥胖和自发性高血压大鼠（SHRs）中进行短期serelaxin治疗（5天），对被动机械壁特性基本没有影响。然而，在SHRs中进行更长时间的serelaxin治疗（14天），可增强大肌性动脉以及阻力大小动脉的被动顺应性。总之，serelaxin具有血管重塑能力。其作用依赖于血管床，在疾病状态下更为显著，且可能需要更长的治疗时间才会有效。
