A reporting system for endometrial cytology: Cytomorphologic criteria-Implied risk of malignancy.
作者信息
Margari Niki, Pouliakis Abraham, Anoinos Dionysios, Terzakis Emmanouil, Koureas Nikolaos, Chrelias Charalampos, Marios Makris George, Pappas Assimakis, Bilirakis Evripidis, Goudeli Christina, Damaskou Vasileia, Papantoniou Nicolaos, Panayiotides Ioannis, Karakitsos Petros
机构信息
Department of Cytopathology, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Athens, 12462, Greece.
2nd Department of Gynecology, "Saint Savvas" Anticancer Hospital, Athens, 11522, Greece.
出版信息
Diagn Cytopathol. 2016 Nov;44(11):888-901. doi: 10.1002/dc.23605. Epub 2016 Sep 22.
BACKGROUND
There have been various attempts to assess endometrial lesions on cytological material obtained via direct endometrial sampling. The majority of efforts focus on the description of cytological criteria that lead to classification systems resembling histological reporting formats. These systems have low reproducibility, especially in cases of atypical hyperplasia and well differentiated carcinomas. Moreover, they are not linked to the implied risk of malignancy.
METHODS
The material was collected from women examined at the outpatient department of four participating hospitals. We analyzed 866 consecutive, histologically confirmed cases. The sample collection was performed using the EndoGyn device, and processed via Liquid Based Cytology, namely ThinPrep technique. The diagnostic categories and criteria were established by two cytopathologists experienced in endometrial cytology; performance of the proposed reporting format was assessed on the basis of histological outcome; moreover, the implied risk of malignancy was calculated.
RESULTS
The proposed six diagnostic categories are as follows: (i) nondiagnostic or unsatisfactory; (ii) without evidence of hyperplasia or malignancy; (iii) atypical cells of endometrium of undetermined significance; (iv) atypical cells of endometrium of low probability for malignancy; (v) atypical cells of endometrium of high probability for malignancy; and (vi) malignant. The risk of malignancy was 1.42% ± 0.98%, 44.44% ± 32.46% (nine cases), 4.30% ± 4.12%, 89.80% ± 8.47%, and 97.81% ± 2.45%, respectively.
CONCLUSION
We propose a clinically oriented classification scheme consisting of diagnostic categories with well determined criteria. Each diagnostic category is linked with an implied risk of malignancy; thus, clinicians may decide on patient management and eventually reduce unnecessary interventional diagnostic procedures. Diagn. Cytopathol. 2016;44:888-901. © 2016 Wiley Periodicals, Inc.
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