生发中心B细胞动力学
Germinal Center B Cell Dynamics.
作者信息
Mesin Luka, Ersching Jonatan, Victora Gabriel D
机构信息
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
出版信息
Immunity. 2016 Sep 20;45(3):471-482. doi: 10.1016/j.immuni.2016.09.001.
Abstract
Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.
摘要
生发中心（GCs）是抗体多样化和亲和力成熟的场所，因此对体液免疫至关重要。在过去10年里，生发中心生物学的研究经历了复兴，一系列的发现改变了我们对亲和力成熟细胞动力学的理解。在这篇综述中，我们讨论了该领域的最新进展，特别强调了生发中心的细胞和克隆动力学如何在免疫反应过程中塑造抗体的亲和力和多样性。
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