Immunity and Cancer Laboratory, The Francis Crick Institute, London, United Kingdom.
Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, United Kingdom.
Front Immunol. 2021 Mar 31;12:661678. doi: 10.3389/fimmu.2021.661678. eCollection 2021.
Germinal centers (GCs) are essential sites for the production of high-affinity antibody secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of vaccination. Affinity maturation and permissive selection in GCs are key for the production of PCs and MBCs, respectively. For these purposes, GCs positively select "fit" cells in the light zone of the GC and instructs them for one of three known B cell fates: PCs, MBCs and persistent GC-B cells as dark zone entrants. In this review, we provide an overview of the positive selection process and discuss its mechanisms and how B cell fates are instructed.
生发中心（GCs）是产生高亲和力抗体分泌浆细胞（PCs）和记忆 B 细胞（MBCs）的关键场所，这些细胞构成了疫苗接种的框架。GC 中的亲和力成熟和允许选择分别是产生 PCs 和 MBCs 的关键。为此，GC 在 GC 的光区中积极选择“合适”的细胞，并指导它们走向三种已知的 B 细胞命运之一：PCs、MBCs 和作为暗区进入者的持续 GC-B 细胞。在这篇综述中，我们提供了对阳性选择过程的概述，并讨论了其机制以及如何指导 B 细胞命运。
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