在接受抗精神病药物治疗的精神分裂症患者中，5-羟色胺受体基因多态性对高催乳素血症的调节作用研究。
Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia.
作者信息
Ivanova Svetlana A, Osmanova Diana Z, Freidin Maxim B, Fedorenko Olga Yu, Boiko Anastasia S, Pozhidaev Ivan V, Semke Arkadiy V, Bokhan Nikolay A, Agarkov Alexey A, Wilffert Bob, Loonen Anton J M
机构信息
a Mental Health Research Institute , Tomsk , Russian Federation.
b National Research Tomsk Polytechnic University , Tomsk , Russian Federation.
出版信息
World J Biol Psychiatry. 2017 Apr;18(3):239-246. doi: 10.1080/15622975.2016.1224926. Epub 2016 Sep 22.
OBJECTIVES
Hyperprolactinaemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 subtype receptors in the pituitary gland. Although dopamine is considered the primary factor inhibiting prolactin release, the activity of prolactin-producing lactotrophs is also regulated by the secretagogues thyrotrophin releasing hormone, vasoactive intestinal polypeptide and serotonin (5-hydroxytryptamine; 5-HT).
METHODS
We describe the association between HPRL and a set of 29 SNPs from 5-HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) who were treated with classical and/or atypical antipsychotic drugs.
RESULTS
None of the studied autosomal markers were found to be associated with HPRL. However, a significant association was established between various HTR2C polymorphisms and HPRL.
CONCLUSIONS
This study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms.
目的
高催乳素血症（HPRL）是抗精神病药物的一种典型副作用，主要归因于垂体中多巴胺D2亚型受体的阻断。尽管多巴胺被认为是抑制催乳素释放的主要因素，但产生催乳素的促乳素细胞的活性也受促分泌素促甲状腺激素释放激素、血管活性肠多肽和5-羟色胺（5-羟色胺；5-HT）的调节。
方法
我们描述了446名临床诊断为精神分裂症（根据ICD-10：F20）的白种人（221名男性/225名女性）群体中HPRL与来自5-HT受体基因HTR1A、HTR1B、HTR2A、HTR2C、HTR3A、HTR3B和HTR6的29个单核苷酸多态性（SNP）之间的关联，这些患者接受了经典和/或非典型抗精神病药物治疗。
结果
未发现所研究的常染色体标记与HPRL相关。然而，各种HTR2C多态性与HPRL之间建立了显著关联。
结论
本研究揭示了HPRL与由rs569959和rs17326429多态性组成的X染色体单倍型之间的关联。
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