人类白细胞抗原-DR表达与宫颈腺癌患者无病生存期和疾病特异性生存期的延长显著相关。

Human Leukocyte Antigen-DR Expression is Significantly Related to an Increased Disease-Free and Disease-Specific Survival in Patients With Cervical Adenocarcinoma.

作者信息

Samuels Sanne, Spaans Vivian M, Osse Michelle, Peters Lex A W, Kenter Gemma G, Fleuren Gertjan J, Jordanova Ekaterina S

机构信息

*Department of Gynaecology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Center Gynaecology Oncology Amsterdam (CGOA), Department of Gynaecology, Netherlands Cancer Institute, Amsterdam, †Department of Gynaecology and Obstetrics, Leiden University Medical Center, Leiden, the Netherlands, ‡Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands; and §Center Gynaecological Oncology Amsterdam (CGOA), Department of Obstetrics and Gynaecology, VU University Medical Centre, Amsterdam, the Netherlands.

出版信息

Int J Gynecol Cancer. 2016 Oct;26(8):1503-1509. doi: 10.1097/IGC.0000000000000783.

DOI:10.1097/IGC.0000000000000783

PMID:27654088

Abstract

OBJECTIVES

Human leukocyte antigen (HLA) class II antigens are expressed on antigen-presenting cells, that is, macrophages, dendritic cells, and B lymphocytes. Under the influence of IFN-γ, HLA class II molecules can also be expressed on T lymphocytes, epithelial and endothelial cells. In addition, HLA class II antigens can be expressed in a variety of malignancies; however, the link with prognosis and ultimately patient survival is controversial.

METHODS

The pattern of HLA-DRA expression in cervical carcinoma was studied using immunohistochemistry. In total, 124 cervical carcinomas were examined, of which 60 (48.4%) were squamous cell carcinomas and 64 (51.6%) were adenocarcinomas.

RESULTS

In squamous cell carcinoma, HLA-DRA was expressed in 41 (68.3%) of 60 tumors, whereas in adenocarcinoma, HLA-DRA was expressed in 60 (93.8%) of 64 tumors (P < 0.001). In adenocarcinoma, HLA-DRA expression was associated with an increased disease-free survival (211.0 ± 13.0 vs 53.3 ± 30.5 months; P = 0.004) and disease-specific survival (226.45 ± 11.5 vs 75.8 ± 27.6 months; P = 0.002).

CONCLUSIONS

Upregulation of HLA-DRA is significantly related to an increased disease-free and disease-specific survival in cervical adenocarcinoma. These data warrant further analysis of the functional role of HLA-DRA in these tumors.

摘要

目的

人类白细胞抗原（HLA）Ⅱ类抗原在抗原呈递细胞上表达，即巨噬细胞、树突状细胞和B淋巴细胞。在干扰素-γ的影响下，HLAⅡ类分子也可在T淋巴细胞、上皮细胞和内皮细胞上表达。此外，HLAⅡ类抗原可在多种恶性肿瘤中表达；然而，其与预后及最终患者生存的关联存在争议。

方法

采用免疫组织化学方法研究宫颈癌中HLA-DRA的表达模式。共检测了124例宫颈癌，其中60例（48.4%）为鳞状细胞癌，64例（51.6%）为腺癌。

结果

在鳞状细胞癌中，60例肿瘤中有41例（68.3%）表达HLA-DRA，而在腺癌中，64例肿瘤中有60例（93.8%）表达HLA-DRA（P<0.001）。在腺癌中，HLA-DRA表达与无病生存期延长（211.0±13.0对53.3±30.5个月；P=0.004）和疾病特异性生存期延长（226.45±11.5对75.8±27.6个月；P=0.002）相关。