拉合尔登革热疫情期间，入院分诊时代谢因素与登革热病毒感染的关联，这些因素可预测其临床病程。

Association of metabolic factors with dengue viral infection on admission triage which predict its clinical course during Lahore dengue epidemic.

作者信息

Baig Mirza Amena Moazzam, Fida Madiha, Murtaza Ghulam, Niazi Rizwan, Hanif Asif, Irfan Khadija, Masud Faisal

机构信息

Department of Endocrinology and Metabolism, Services Hospital, Lahore.

House Officer, Lahore.

出版信息

J Pak Med Assoc. 2016 Sep;66(9):1102-1106.

PMID:27654728

Abstract

OBJECTIVE

The study was done to identify metabolic factors which were associated with an increased risk of dengue haemorrhagic fever in clinically diagnosed patients of dengue viral infection.

METHODS

563 patients with dengue viral infection that presented to 3 tertiary care hospitals of Lahore were included in this study, out of which approximately half of the patients were diagnosed as dengue haemorrhagic fever.

RESULTS

A total of 563 patients with 263(46.7%) dengue fever and 300(53.3%) dengue haemorrhagic fever patients were studied. The mean age of patients was 48.48 ± 20.07 years. In patients younger than 60 (n=355), 171 patients had DF and 184 had DHF, while 116 patients above 60 years had DHF and 92 had DF (n=208). The presence of metabolic risk factors such as diabetes (OR = 2.146), hypertension (OR =1.65), diabetes and hypertension (OR =3.56), abnormal liver function tests (OR = 2.27), abnormal renal function tests (OR = 2.282) all increased the risk of DHF relative to DF.

CONCLUSIONS

The study showed that metabolic factors especially diabetes with and without hypertension are important risk factors for the development of DHF.

摘要

目的

本研究旨在确定在临床诊断的登革病毒感染患者中，与登革出血热风险增加相关的代谢因素。

方法

本研究纳入了拉合尔3家三级医疗医院的563例登革病毒感染患者，其中约一半患者被诊断为登革出血热。

结果

共研究了563例患者，其中263例（46.7%）为登革热患者，300例（53.3%）为登革出血热患者。患者的平均年龄为48.48±20.07岁。在60岁以下的患者（n=355）中，171例患有登革热，184例患有登革出血热；而在60岁以上的患者（n=208）中，116例患有登革出血热，92例患有登革热。糖尿病（OR=2.146）、高血压（OR=1.65）、糖尿病合并高血压（OR=3.56）、肝功能检查异常（OR=2.27）、肾功能检查异常（OR=2.282）等代谢危险因素相对于登革热均增加了登革出血热的风险。