Zeng Jing, Liao Wei
Department of Pediatrics, Southwest Hospital of The Third Military Medical University, Chongqing 400038, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Sep;18(9):903-908. doi: 10.7499/j.issn.1008-8830.2016.09.022.
Bronchial asthma is a heterogeneous disease that is characterized by airway hyperresponsiveness and chronic inflammation. It is often accompanied by reversible airflow obstruction. Current laboratory testing methods for the diagnosis of asthma in children mainly include lung ventilation function test. Due to the non-cooperation of children, it is very challenging to conduct lung ventilation function test for preschoolers. Lung function testing is an instantaneous indicator, which is influenced by the children's understanding ability and mental factors. In addition, it could not assess the severity of airway inflammation. Fractional exhaled nitric oxide (FeNO) is a noninvasive, simple, and objective indicator of airway inflammation and has gradually gained increased use in children in recent years. This review article introduces the source of FeNO, the reference value of FeNO in laboratory testing, and the progress in the application of FeNO in the diagnosis, prediction, and treatment of asthma in children of various ages.
支气管哮喘是一种异质性疾病，其特征为气道高反应性和慢性炎症。它常伴有可逆性气流受限。目前儿童哮喘诊断的实验室检测方法主要包括肺通气功能检测。由于儿童不配合，对学龄前儿童进行肺通气功能检测极具挑战性。肺功能检测是一个即时指标，受儿童理解能力和心理因素影响。此外，它无法评估气道炎症的严重程度。呼出一氧化氮分数（FeNO）是一种无创、简单且客观的气道炎症指标，近年来在儿童中逐渐得到更广泛应用。本文综述介绍了FeNO的来源、实验室检测中FeNO的参考值，以及FeNO在各年龄段儿童哮喘诊断、预测和治疗中的应用进展。
